Journal article
Effects of LSD, Ritanserin, 8-OH-DPAT, and Lisuride on Classical Conditioning in the Rabbit
Pharmacology, biochemistry and behavior, Vol.59(2), pp.469-475
1998
PMID: 9476997
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
d-Lysergic acid diethylamide (LSD), an agonist at the 5-HT
2A/2C and 5-HT
1A receptors, has previously been demonstrated to enhance associative learning as measured by accelerated acquisition of the rabbit’s classically conditioned nictitating membrane (NM) response. The present study examined further the role of these receptors in the action of LSD. LSD (30 nmol/kg, IV) significantly enhanced conditioned response (CR) acquisition to both tone and light conditioned stimuli (CSs), while the 5-HT
1A receptor agonists 8-hydroxy-2-(dipropylamino)tetralin (8-OH-DPAT; 50 and 200 nmol/kg) and lisuride (0.3–30 nmol/kg) had no effect. Ritanserin (6.7–6700 nmol/kg, SC), a selective 5-HT
2A/2C receptor antagonist, retarded acquisition of CRs to both tone and light CSs in a dose-dependent manner. Ritanserin (6.7–670 nmol/kg, SC) also dose dependently antagonized the enhancement of CR conditioning produced by LSD (30 nmol/kg, IV) to both tone and light CSs. We conclude that the enhancement of CR acquisition by LSD was due to an action at the 5-HT
2A/2C receptor. These results suggest that the 5-HT
2A/2C receptor plays an important role in learning.
Metrics
3 Record Views
Details
- Title
- Effects of LSD, Ritanserin, 8-OH-DPAT, and Lisuride on Classical Conditioning in the Rabbit
- Creators
- S.E Welsh - Division of Behavioral Neurobiology, Department of Pharmacology, Allegheny University of the Health Sciences, Philadelphia, PA 19129 USAW.J Kachelries - Division of Behavioral Neurobiology, Department of Pharmacology, Allegheny University of the Health Sciences, Philadelphia, PA 19129 USAA.G Romano - Division of Behavioral Neurobiology, Department of Pharmacology, Allegheny University of the Health Sciences, Philadelphia, PA 19129 USAK.J Simansky - Division of Behavioral Neurobiology, Department of Pharmacology, Allegheny University of the Health Sciences, Philadelphia, PA 19129 USAJ.A Harvey - Division of Behavioral Neurobiology, Department of Pharmacology, Allegheny University of the Health Sciences, Philadelphia, PA 19129 USA
- Publication Details
- Pharmacology, biochemistry and behavior, Vol.59(2), pp.469-475
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- MD (Doctor of Medicine) Program; Pharmacology and Physiology
- Identifiers
- 991014877818704721
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Web of Science research areas
- Behavioral Sciences
- Neurosciences
- Pharmacology & Pharmacy