Journal article
Effects of Neuronal Activity on Inositol Phospholipid Metabolism in the Rat Autonomic Nervous System
Journal of neurochemistry, v 44(3), pp 731-739
Mar 1985
PMID: 3973589
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
: The effect of nerve stimulation on inositol phospholipid hydrolysis in autonomie tissue was assessed by direct measurement of [3H]inositol phosphate production in ganglia that had been preincubated with [3H]inositol. Within minutes, stimulation of the preganglionic nerve increased the [3H]inositol phosphate content of the superior cervical sympathetic ganglion indicating increased hydrolysis of inositol phospholipids. This effect was blocked in a low Ca2+, high Mg2+ medium. It was also greatly reduced when nicotinic and muscarinic antagonists were present together in normal medium. However, neither the nicotinic antagonist nor the muscarinic antagonist alone appeared to be as effective as both in combination. In other experiments, stimulation of the vagus nerve caused dramatic increases in [3H]inositol phosphate in the nodose ganglion but did not increase [3H]inositol phosphate in the nerve itself. This effect was insensitive to the cholinergic antagonists. Thus, neuronal activity increased inositol phospholipid hydrolysis in a sympathetic ganglion rich in synapses, as well as in a sensory ganglion that contains few synapses. In the sympathetic ganglion, synaptic stimulation activated inositol phospholipid hydrolysis and this was primarily due to cholinergic transmission; both nicotinic and muscarinic pathways appeared to be involved.
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Details
- Title
- Effects of Neuronal Activity on Inositol Phospholipid Metabolism in the Rat Autonomic Nervous System
- Creators
- Clark A. BriggsJoel HorwitzDonald A. McAfeeSophia TsymbalovRobert L. Perlman
- Publication Details
- Journal of neurochemistry, v 44(3), pp 731-739
- Publisher
- Blackwell Publishing Ltd
- Number of pages
- 9
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:A1985ACC6900012
- Scopus ID
- 2-s2.0-0021997865
- Other Identifier
- 991020531958604721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Biochemistry & Molecular Biology
- Neurosciences