Journal article
Effects of Opiates and HIV Proteins on Neurons: The Role of Ferritin Heavy Chain and a Potential for Synergism
Current HIV research, v 10(5), pp 453-462
Jul 2012
PMID: 22591369
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Human immunodeficiency virus 1 (HIV-1) and its associated proteins can have a profound impact on the central nervous system. Co-morbid abuse of opiates, such as morphine and heroin, is often associated with rapid disease progression and greater neurological dysfunction. The mechanisms by which HIV proteins and opiates cause neuronal damage on their own and together are unclear. The emergence of ferritin heavy chain (FHC) as a negative regulator of the chemokine receptor CXCR4, a co-receptor for HIV, may prove to be important in elucidating the interaction between HIV proteins and opiates. This review summarizes our current knowledge of central nervous system damage inflicted by HIV and opiates, as well as the regulation of CXCR4 by opiate-induced changes in FHC protein levels. We propose that HIV proteins and opiates exhibit an additive or synergistic effect on FHC/CXCR4, thereby decreasing neuronal signaling and function.
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Details
- Title
- Effects of Opiates and HIV Proteins on Neurons: The Role of Ferritin Heavy Chain and a Potential for Synergism
- Creators
- Lindsay Festa - Department of Pharmacology and Physiology, Drexel University College of Medicine, 245 N. 15Olimpia Meucci - Department of Pharmacology and Physiology, Drexel University College of Medicine, 245 N. 15
- Publication Details
- Current HIV research, v 10(5), pp 453-462
- Publisher
- Bentham
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:000308004200011
- Scopus ID
- 2-s2.0-84866332761
- Other Identifier
- 991014877909904721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Immunology
- Infectious Diseases
- Virology