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Journal article
Effects of Prescribed Medications on Cognition and Behavior in Frontotemporal Lobar Degeneration
American journal of Alzheimer's disease and other dementias, v 25(7), pp 566-571
01 Nov 2010
PMID: 20930186
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
A retrospective chart review of 21 patients meeting core clinical criteria for behavioral or aphasic variants of frontotemporal lobar degeneration (FTLD) was conducted. Data recorded included Folstein Mini-Mental State Examination (MMSE) scores, medications prescribed, and subjective reports of behavioral symptoms from each visit. Behaviors were graded on a scale from 1 to 3 and totaled for each visit. Changes in MMSE and behavior scores between visits 1 month and 6 months apart where a new medication was started were analyzed using a paired t test and were compared between medication classes using an unpaired t test. Acetylcholinesterase inhibitors (AChEIs) were associated with a decrease in MMSE scores by 1.6 (P = .02) and an increase in total behavior scores by 1.0 (P = .03). Mean MMSE and behavior scores were statistically more improved by selective serotonin reuptake inhibitors than AChEIs (P = .04). This data suggest a potential worsening of objective measures of cognitive and behavioral symptoms in FTLD with AChEI treatment.
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Details
- Title
- Effects of Prescribed Medications on Cognition and Behavior in Frontotemporal Lobar Degeneration
- Creators
- David Irwin - Drexel UniversityCarol F. Lippa - Drexel UniversityAndrea Rosso - Drexel University
- Publication Details
- American journal of Alzheimer's disease and other dementias, v 25(7), pp 566-571
- Publisher
- Sage
- Number of pages
- 6
- Resource Type
- Journal article
- Language
- English
- Web of Science ID
- WOS:000282645000005
- Scopus ID
- 2-s2.0-77957955894
- Other Identifier
- 991019312358704721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Clinical Neurology
- Geriatrics & Gerontology