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Journal article
Effects of Prestretch on Neonatal Peripheral Nerve: An In Vitro Study
Journal of brachial plexus and peripheral nerve injury, v 17(1), pp E1-E9
01 Jan 2022
PMID: 35400085
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background Characterizing the biomechanical failure responses of neonatal peripheral nerves is critical in understanding stretch-related peripheral nerve injury mechanisms in neonates.
Objective This in vitro study investigated the effects of prestretch magnitude and duration on the biomechanical failure behavior of neonatal piglet brachial plexus (BP) and tibial nerves.
Methods BP and tibial nerves from 32 neonatal piglets were harvested and pre-stretched to 0, 10, or 20% strain for 90 or 300 seconds. These prestretched samples were then subjected to tensile loading until failure. Failure stress and strain were calculated from the obtained load-displacement data.
Results Prestretch magnitude significantly affected failure stress but not the failure strain. BP nerves prestretched to 10 or 20% strain, exhibiting significantly lower failure stress than those prestretched to 0% strain for both prestretch durations (90 and 300 seconds). Likewise, tibial nerves prestretched to 10 or 20% strain for 300 seconds, exhibiting significantly lower failure stress than the 0% prestretch group. An effect of prestretch duration on failure stress was also observed in the BP nerves when subjected to 20% prestretch strain such that the failure stress was significantly lower for 300 seconds group than 90 seconds group. No significant differences in the failure strains were observed. When comparing BP and tibial nerve failure responses, significantly higher failure stress was reported in tibial nerve prestretched to 20% strain for 300 seconds than BP nerve.
Conclusion These data suggest that neonatal peripheral nerves exhibit lower injury thresholds with increasing prestretch magnitude and duration while exhibiting regional differences.
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Details
- Title
- Effects of Prestretch on Neonatal Peripheral Nerve: An In Vitro Study
- Creators
- Anita Singh - Widener UniversityTanmay Majmudar - Drexel UniversityRachel Magee - Drexel UniversityBernard Gonik - Wayne State UniversitySriram Balasubramanian - Drexel University
- Publication Details
- Journal of brachial plexus and peripheral nerve injury, v 17(1), pp E1-E9
- Publisher
- Thieme Medical Publishers
- Number of pages
- 9
- Grant note
- 1752513 / National Science Foundation (NSF) Faculty Early Career Development (CAREER); National Science Foundation (NSF) R15HD093024 / Eunice Kennedy Shriver National Institute of Child Health and Human Development of the National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine; School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000779468900001
- Scopus ID
- 2-s2.0-85128376831
- Other Identifier
- 991019167533904721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Clinical Neurology