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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Effects of Recent Alcohol Consumption Level on Neurocognitive Performance in HIV+ Individuals
Addictive disorders & their treatment, v 16(3), pp 95-107
01 Sep 2017
PMID: 29081720
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Objectives:
Although HIV+ individuals may be at increased risk of alcohol-related cognitive impairment, the relations between drinking level and cognitive performance in these individuals are not well understood. We examined whether higher levels of recent drinking in HIV+ individuals were associated with poorer cognitive performance, particularly in executive functioning and memory.
Materials and Methods:
We administered a comprehensive cognitive battery to 120 seropositive subjects (101 men) who reported alcohol consumption in the preceding 90 days. Participants were excluded if they were seeking alcohol treatment or showed evidence of dementia. Using the computerized CogState battery, we measured performance in executive functioning, verbal learning/memory, visual learning/memory, attention, working memory, and psychomotor speed. The computerized Iowa Gambling Task was used to assess decision-making.
Results:
The HIV+ subjects showed significantly slower psychomotor speed than a normative sample. Although across most domains, neurocognitive performance in our sample was not significantly associated with recent alcohol consumption, performance on the CogState measures of visual memory and attention was significantly poorer with a higher level of drinking in the past 3 months and a current alcohol use disorder, respectively.
Conclusions:
Although cognitive weaknesses were detectable among these non-treatment-seeking HIV+ drinkers, the level of alcohol consumption was not a primary determinant of neurocognitive performance in this group. A comprehensive profile analysis may be most valuable for detecting cognitive strengths and weaknesses given the heterogeneity of this population. Longitudinal studies are needed to examine the potential additive or synergistic effects of heavy drinking and HIV seropositivity on cognitive performance.
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Details
- Title
- Effects of Recent Alcohol Consumption Level on Neurocognitive Performance in HIV+ Individuals
- Creators
- Kara R. Douglas-Newman - Behavioral Health ServicesRachel V. Smith - Behavioral Health ServicesMary V. Spiers - Drexel UniversityTimothy Pond - Center for Studies of Addiction, Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, 3535 Market Street, Philadelphia, PA 19104.Henry R. Kranzler - Behavioral Health Services
- Publication Details
- Addictive disorders & their treatment, v 16(3), pp 95-107
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 13
- Grant note
- AbbVie XenoPort P30 AI045008; K24 AA013736 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA Indivior Pfizer K24AA013736 / NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Alcohol Abuse & Alcoholism (NIAAA) Otsuka; Otsuka Pharmaceutical Lilly; Eli Lilly P30AI045008 / NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID) Ethypharm Lundbeck; Lundbeck Corporation Alkermes
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- [Retired Faculty]
- Web of Science ID
- WOS:000416713800001
- Scopus ID
- 2-s2.0-85020688858
- Other Identifier
- 991019168329304721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Substance Abuse