Journal article
Effects of Valproic Acid on Longitudinal Bone Growth
Journal of child neurology, v 19(1)
Jan 2004
PMID: 15032379
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Valproic acid is widely used in the treatment of children with epilepsy. Evidence indicates that valproic acid has teratogenic effects on the skeletal system. In addition, the use of valproic acid in children has been associated with short stature. Thus, we hypothesized that valproic acid could also affect bone growth after skeletal morphogenesis is completed. To test this hypothesis, we cultured fetal rat metatarsal bones in the presence of valproic acid. Valproic acid markedly suppressed metatarsal longitudinal growth. To determine the underlying mechanisms, we studied cell proliferation and hypertrophy in the growth plate, the site where bone growth takes place. At the end of the culture period, valproic acid—treated bones exhibited narrow growth plate proliferative and hypertrophic zones and an expanded ossification center. In addition, valproic acid suppressed chondrocyte proliferation in the metatarsal rudiments. Our results suggest that valproic acid suppresses longitudinal bone growth by inhibiting cartilage formation and accelerating ossification of the growth plate. These findings warrant a prospective study on the effects of valproic acid on growth in children treated with valproic acid. ( J Child Neurol 2004;19:26—30).
Metrics
Details
- Title
- Effects of Valproic Acid on Longitudinal Bone Growth
- Creators
- Shufang Wu - St. Christopher's Hospital for ChildrenAgustin Legido - St. Christopher's Hospital for ChildrenFrancesco De Luca - St. Christopher's Hospital for ChildrenFrancesco DeLuca - Pediatrics
- Publication Details
- Journal of child neurology, v 19(1)
- Publisher
- Sage
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics; College of Medicine
- Web of Science ID
- WOS:000189329900005
- Scopus ID
- 2-s2.0-1542603370
- Other Identifier
- 991019168914504721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Clinical Neurology
- Pediatrics