Journal article
Effects of aging and degeneration on the human intervertebral disc during the diurnal cycle: A finite element study
Journal of orthopaedic research, v 30(1), pp 122-128
01 Jan 2012
PMID: 21710607
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
A significant biochemical change that takes place in intervertebral disc degeneration is the loss of proteoglycans in the nucleus pulposus. Proteoglycans attract fluid, which works to reduce mechanical stresses in the solid matrix of the nucleus and provide a hydrostatic pressure to the annulus fibrosus, whose fibrous nature accommodates this stress. Our goals are to develop an osmo-poroelastic finite element model to study the relationship between proteoglycan content and the stress distribution within the disc and to analyze the effects of degeneration on the disc's diurnal mechanical response. Stress in the annulus increased with degeneration from similar to 0.2 to 0.4?MPa, and an increase occurred in the center of the nucleus from 1.2 to 1.6?MPa. The osmotic pressure in the central nucleus region decreased the most with degeneration, from similar to 0.42 to similar to 0.1?MPa in a severely dehydrated disc. A 3% decrease in diurnal fluid lost with degeneration equated to similar to 21% decrease in fluid exchange, and hence a decrease in nutrients that require convection to enter the disc. We quantified the increases in internal stresses in the nucleus and annulus throughout the various stages of degeneration, suggesting that these changes lead to further remodeling of the tissue. (c) 2011 Orthopaedic Research Society Published by Wiley Periodicals, Inc. J Orthop Res 30:122128, 2012
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Details
- Title
- Effects of aging and degeneration on the human intervertebral disc during the diurnal cycle: A finite element study
- Creators
- Christopher J. Massey - Drexel UniversityCorrinus C. van Donkelaar - Eindhoven University of TechnologyEdward Vresilovic - Pennsylvania State UniversityAntonios Zavaliangos - Drexel UniversityMichele Marcolongo - Drexel University
- Publication Details
- Journal of orthopaedic research, v 30(1), pp 122-128
- Publisher
- Wiley
- Number of pages
- 7
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Materials Science and Engineering
- Web of Science ID
- WOS:000297913600016
- Scopus ID
- 2-s2.0-81555203465
- Other Identifier
- 991019168461804721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Orthopedics