Journal article
Effects of bepridil hydrochloride on cardiocirculatory dynamics and cardiac output distribution in conscious rat
Federation proceedings, Vol.44(5), pp.1642-1642
01 Jan 1985
Abstract
By reducing cellular free calcium (Ca), Ca antagonists cause vasodilation and negative cardiac inotropic effects. The latter is often not seen in vivo due to reflex increases in sympathetic tone (i.e. nifedipine (NF)). The Ca antagonists, bepridil hydrochloride (BP) and NF, were studied in conscious normal rats instrumented for hemodynamic recording and for the radioactive microsphere technique. The results suggest that while BP and NF were similarly selective coronary dilators, BP had additional beneficial cardiac effects in that BP reduced HR and PRP but NF did not. Thus, BP may improve cardiac efficiency by decreasing myocardial oxygen demand and by increasing myocardial oxygen supply.
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Details
- Title
- Effects of bepridil hydrochloride on cardiocirculatory dynamics and cardiac output distribution in conscious rat
- Creators
- M StranieriJ MathiasenS Flaim
- Publication Details
- Federation proceedings, Vol.44(5), pp.1642-1642
- Number of pages
- 1
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Identifiers
- 991021900018104721