Journal article
Effects of crowders on the equilibrium and kinetic properties of protein aggregation
Chemical physics letters, v 659, pp 252-257
16 Aug 2016
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The equilibrium and kinetic properties of protein aggregation systems in the presence of crowders are investigated using simple, illuminating models based on mass-action laws. Our model yields analytic results for equilibrium properties of protein aggregates, which fit experimental data of actin and ApoC-II with crowders reasonably well. When the effects of crowders on rate constants are considered, our kinetic model is in good agreement with experimental results for actin with dextran as the crowder. Furthermore, the model shows that as crowder volume fraction increases, the length distribution of fibrils becomes narrower and shifts to shorter values due to volume exclusion. (C) 2016 Elsevier B.V. All rights reserved.
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Details
- Title
- Effects of crowders on the equilibrium and kinetic properties of protein aggregation
- Creators
- John Bridstrup - Drexel UniversityJian-Min Yuan - Drexel University
- Publication Details
- Chemical physics letters, v 659, pp 252-257
- Publisher
- Elsevier
- Number of pages
- 6
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Physics
- Web of Science ID
- WOS:000383009700048
- Scopus ID
- 2-s2.0-84979500358
- Other Identifier
- 991019168311004721
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- Web of Science research areas
- Chemistry, Physical
- Physics, Atomic, Molecular & Chemical