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Effects of endotracheally administered distilled water and normal saline on the arterial blood gases of dogs
Journal article   Peer reviewed

Effects of endotracheally administered distilled water and normal saline on the arterial blood gases of dogs

Michael I. Greenberg, Steven I. Baskin, Adele M. Kaplan and Francis J. Urrichio
Annals of emergency medicine, v 11(11), pp 600-604
1982
DOI: https://doi.org/10.1016/S0196-0644(82)80200-X
PMID: 6814311
Featured in Collection :   UN Sustainable Development Goals @ Drexel

Abstract

arterial blood gases endotracheal administration near drowning
The effects of endotracheally (ET) administered distilled water (DW) and normal saline solution (NSS) on the arterial blood gases of dogs were compared. When distilled water was administered endotracheally, arterial pH was depressed to 99.36% of baseline values within 5 minutes. When compared to pH changes following ET administration of NSS the depression of pH following DW administration was significant (P < .05). Following ET injection of DW, arterial PO 2 was depressed to 61% of baseline values and remained significantly depressed throughout the experiment. In comparison, following ET NSS administration, PO 2 was depressed substantially less, and remained at significantly higher levels for the entire experiment. In dogs, administration of NSS by the ET route produces less detrimental effects on arterial blood gases than does the ET administration of DW. This may have implications for the choice of diluent for human drug administration using the ET route.

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23 citations in Web of Science
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Web of Science research areas
Emergency Medicine
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