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Journal article
Effects of epinephrine on angiogenesis-related gene expressions in cultured rat cardiomyocytes
Journal of biomedical research, v 30(5), pp 380-385
30 Apr 2016
PMID: 27845301
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Epinephrine is often used for the treatment of patients with heart failure, low cardiac output and cardiac arrest. It can acutely improve hemodynamic parameters; however, it does not seem to improve longer term clinical outcomes. Therefore, we hypothesized that epinephrine may induce unfavorable changes in gene expression of cardiomyocyte. Thus, we investigated effects of epinephrine exposure on the mediation or modulation of gene expression of cultured cardiomyocytes at a genome-wide scale. Our investigation revealed that exposure of cardiomyocytes to epinephrine in an
in vitro
environment can up-regulate the expression of angiopoietin-2 gene (+2.1 times), and down-regulate the gene expression of neuregulin 1 (−3.7 times), plasminogen activator inhibitor-1 (−2.4 times) and SPARC-related modular calcium-binding protein-2 (−4.5 times). These changes suggest that epinephrine exposure may induce inhibition of angiogenesis-related gene expressions in cultured rat cardiomyocytes. The precise clinical significance of these changes in gene expression, which was induced by epinephrine exposure, warrants further experimental and clinical investigations.
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Details
- Title
- Effects of epinephrine on angiogenesis-related gene expressions in cultured rat cardiomyocytes
- Creators
- Henry Liu - Hahnemann University HospitalLisa Sangkum - Hahnemann University HospitalGeoffrey Liu - Hahnemann University HospitalMichael Green - Hahnemann University HospitalMarilyn Li - Children's Hospital of PhiladelphiaAlan Kaye - Louisiana State University Health Sciences Center New Orleans
- Publication Details
- Journal of biomedical research, v 30(5), pp 380-385
- Publisher
- Editorial Department of Journal of Biomedical Research
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Anesthesiology and Perioperative Medicine
- Web of Science ID
- WOS:000384640500005
- Scopus ID
- 2-s2.0-84992463250
- Other Identifier
- 991019168018004721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Medicine, Research & Experimental