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Effects of histone deacetylase inhibitors on HIF-1
Journal article   Open access   Peer reviewed

Effects of histone deacetylase inhibitors on HIF-1

Dongming Liang, Xianguo Kong and Nianli Sang
Cell cycle (Georgetown, Tex.), v 5(21), pp 2430-2435
01 Nov 2006
DOI: https://doi.org/10.4161/cc.5.21.3409
PMID: 17102633
Featured in Collection :   UN Sustainable Development Goals @ Drexel
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https://doi.org/10.4161/cc.5.21.3409View
Published, Version of Record (VoR) Open

Abstract

Neoplasms - metabolism Humans Transcriptional Activation Enzyme Inhibitors - pharmacology Gene Expression Regulation Neovascularization, Pathologic Oxygen - metabolism Neoplasms - drug therapy Transcription Factors - metabolism Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Models, Biological Enzyme Inhibitors - chemistry Hypoxia Histone Deacetylase Inhibitors Histones - metabolism Neoplasms - pathology
Hypoxia inducible factors (HIF) are the master transcriptional regulators of angiogenesis and energy metabolism in mammals. Histone deacetylase inhibitors (HDAIs) are among the promising anti -cancer compounds currently in clinical trials. In addition to inducing hyperacetylation of histones, HDAIs have been found to repress HIF function, which has been construed as an important pharmacological mechanism underlying the HDAI -mediated repression of tumor growth and angiogenesis. While HDAIs are potent inhibitors of HIF function and thus may be useful in the prevention and treatment of cancers, a major dilemma is that they may induce hyperacetylation of nonspecific targets thus causing side effects. A better understanding is now required of the molecular and biochemical mechanisms underlying the anti -HIF effects of these compounds. Here we summarize the recent advances towards a better understanding of these molecular and biochemical mechanisms.

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Cell Biology
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