Journal article
Effects of in utero alcohol exposure on B cell development in neonatal spleen and bone marrow
Cellular immunology, v 191(2)
01 Feb 1999
PMID: 9973534
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The effects of in utero alcohol exposure on neonatal lymphopoiesis were examined in a murine model of fetal alcohol syndrome. At birth, both immature and mature B cells were decreased in the spleens of neonatal animals and these subpopulations of B cells did not recover to normal levels until 3-4 weeks of life. Pre-B cells and total B cells were decreased as well in the bone marrow of ethanol-exposed animals. By 3-4 weeks of life, the number of B cells in the bone marrow recovered to normal levels, but the pre-B cells remained below normal levels through 5 weeks of age. Furthermore, a recently described early B cell progenitor was reduced in frequency in ethanol-exposed neonates. Together, these data suggest that in utero exposure to ethanol can result in abnormalities in B cell development that may initiate at an early stage of B cell development.
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Details
- Title
- Effects of in utero alcohol exposure on B cell development in neonatal spleen and bone marrow
- Creators
- K M Moscatello - Department of Microbiology and Immunology, Louisiana State University Medical Center, 1501 Kings Highway, Shreveport, Louisiana, 71130, USAK L BiberS R JenningsR ChervenakR M Wolcott
- Publication Details
- Cellular immunology, v 191(2)
- Publisher
- Netherlands
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000078685000006
- Scopus ID
- 2-s2.0-0033082825
- Other Identifier
- 991014878177804721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Cell Biology
- Immunology