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Journal article
Effects of inoculating dose on the kinetics of Chlamydia muridarum genital infection in female mice
Immunology and cell biology, v 87(4), pp 337-343
01 May 2009
PMID: 19204735
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Abstract
Chlamydia trachomatis infections have been implicated in problems such as pelvic inflammatory disease and infertility in females. Although there are some studies examining the kinetics of ascending infection, there is limited information on the kinetics of pathology development and cellular infiltrate into the reproductive tissues in relation to the effects of inoculating dose, and a better understanding of these is needed. The murine model of female genital tract Chlamydia muridarum infection is frequently used as a model of human C. trachomatis reproductive tract infection. To investigate the kinetics of ascending genital infection and associated pathology development, female BALB/c mice were intravaginally infected with C. muridarum at doses ranging from 5 x 10(2) to 2.6 x 10(6) inclusion forming units. We found that the inoculating dose affects the course of infection and the ascension of bacteria, with the highest dose ascending rapidly to the oviducts. By comparison, the lowest dose resulted in the greatest bacterial load in the lower reproductive tract. Interestingly, we found that the dose did not significantly affect inflammatory cell infiltrate in the various regions. Overall, this data show the effects of infectious dose on the kinetics of ascending chlamydial infection and associated inflammatory infiltration in BALB/c mice. Immunology and Cell Biology ( 2009) 87, 337-343; doi:10.1038/icb.2009.3; published online 10 February 2009
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Details
- Title
- Effects of inoculating dose on the kinetics of Chlamydia muridarum genital infection in female mice
- Creators
- Alison J. Carey - Queensland University of TechnologyKelly A. Cunningham - Queensland University of TechnologyLouise M. Hafner - Queensland University of TechnologyPeter Timms - Queensland University of TechnologyKenneth W. Beagley - Queensland University of Technology
- Publication Details
- Immunology and cell biology, v 87(4), pp 337-343
- Publisher
- Wiley
- Number of pages
- 7
- Grant note
- 351113 / Australian National Health and Medical Research Council; National Health and Medical Research Council (NHMRC) of Australia 497260 / National Health and Medical Research Council Postgraduate Training Scholarship; National Health and Medical Research Council (NHMRC) of Australia
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics; College of Medicine; Drexel University
- Web of Science ID
- WOS:000266208800011
- Scopus ID
- 2-s2.0-67349153120
- Other Identifier
- 991020100056704721
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Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Cell Biology
- Immunology