Journal article
Effects of neonatal castration or treatment with dihydrotestosterone on numbers of neurons in the rat superior cervical sympathetic ganglion
Brain research. Developmental brain research, v 20(2), pp 314-316
1985
PMID: 4027673
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
There is a normal sexual dimorphism in the number of neurons in the rat superior cervical sympathetic ganglion (SCG), with adult males having more neurons in this ganglion than females
15. We confirm this finding here, report that this sex difference is not present at birth and that neonatal castration of males reduces the adult sex difference. These results indicate that perinatal levels of circulating testicular hormones play a role in regulating the numbers of neurons in the SCG. Treatment of neonatal rats with testosterone propionate or estradiol significantly increases the number of neurons in the SCG. To determine whether this effect is primary androgenic or estrogenic, the effects of dihydrotestosterone, on SCG neuron number were investigated. Dihydrotestosterone, unlike testosterone, is not aromatized to estradiol intracellularly. There was no difference in the number of neurons between animals injected from birth with vehicle or dihydrotestosterone. This difference in effects between dihydrotestosterone and testosterone suggests that the actions of testosterone may be via aromatization to estradiol, rather than action at an androgen receptor.
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Details
- Title
- Effects of neonatal castration or treatment with dihydrotestosterone on numbers of neurons in the rat superior cervical sympathetic ganglion
- Creators
- Linda L. Wright - Boston UniversityArnold J. Smolen - Drexel University
- Publication Details
- Brain research. Developmental brain research, v 20(2), pp 314-316
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- MD (Doctor of Medicine) Program
- Web of Science ID
- WOS:A1985AMW5700022
- Scopus ID
- 2-s2.0-0021880317
- Other Identifier
- 991019184183404721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Developmental Biology
- Neurosciences