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Effects of perinatal exposure to palatable diets on body weight and sensitivity to drugs of abuse in rats
Journal article   Open access   Peer reviewed

Effects of perinatal exposure to palatable diets on body weight and sensitivity to drugs of abuse in rats

Miriam E. Bocarsly, Jessica R. Barson, Jenna M. Hauca, Bartley G. Hoebel, Sarah F. Leibowitz and Nicole M. Avena
Physiology & behavior, v 107(4), pp 568-575
05 Nov 2012
DOI: https://doi.org/10.1016/j.physbeh.2012.04.024
PMID: 22564493
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://europepmc.org/articles/pmc3484233View
Accepted (AM) Open Open Access (License Unspecified)

Abstract

Behavioral Sciences Life Sciences & Biomedicine Psychology Psychology, Biological Science & Technology Social Sciences
The aim of the present study was to determine the effects of fat- and sugar-rich diets in utero and during the pre-weaning period on bodyweight and responses to drugs of abuse. In Exp. 1, dams were fed a balanced control diet or high-fat diet (HFD), and female offspring were cross-fostered to dams consuming the balanced diet. The HFD-exposed offspring, compared to controls, were heavier in body weight, had increased circulating triglyceride levels, and consumed more alcohol-and HFD in adulthood. In Exp. 2, dams were fed standard chow alone or standard chow plus a 16% high-fructose corn syrup (HFCS) or 10% sucrose solution. Sets of offspring from each group were cross-fostered to dams in the other groups, allowing for the effects of HFCS or sucrose exposure during the gestational period or pre-weaning period to be determined. The offspring (both female and male) exposed to HFCS or sucrose in utero had higher body weights in adulthood and exhibited increased alcohol intake as shown in female offspring and increased amphetamine-induced locomotor activity as shown in males. Exposure to HFCS or sucrose only during the pre-weaning period had a similar effect of increasing amphetamine-induced locomotor activity in males, but produced no change in circulating triglycerides or alcohol intake. Collectively, these data suggest that prenatal as well as pre-weaning exposure to fat- and sugar-rich diets, in addition to increasing body weight, can affect responses to drugs of abuse. (C) 2012 Elsevier Inc. All rights reserved.

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UN Sustainable Development Goals (SDGs)

This publication has contributed to the advancement of the following goals:

#5 Gender Equality
#3 Good Health and Well-Being

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Collaboration types
Domestic collaboration
Web of Science research areas
Behavioral Sciences
Psychology, Biological
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