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Journal article
Effects of persistent modulation of intestinal microbiota on SIV/HIV vaccination in rhesus macaques
npj vaccines, v 6(1), pp 34-34
11 Mar 2021
PMID: 33707443
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
An effective vaccine to prevent HIV transmission has not yet been achieved. Modulation of the microbiome via probiotic therapy has been suggested to result in enhanced mucosal immunity. Here, we evaluated whether probiotic therapy could improve the immunogenicity and protective efficacy of SIV/HIV vaccination. Rhesus macaques were co-immunized with an SIV/HIV DNA vaccine via particle-mediated epidermal delivery and an HIV protein vaccine administered intramuscularly with Adjuplex™ adjuvant, while receiving daily oral Visbiome
probiotics. Probiotic therapy alone led to reduced frequencies of colonic CCR5
and CCR6
CD4
T cells. Probiotics with SIV/HIV vaccination led to similar reductions in colonic CCR5
CD4
T cell frequencies. SIV/HIV-specific T cell and antibody responses were readily detected in the periphery of vaccinated animals but were not enhanced with probiotic treatment. Combination probiotics and vaccination did not impact rectal SIV/HIV target populations or reduce the rate of heterologous SHIV acquisition during the intrarectal challenge. Finally, post-infection viral kinetics were similar between all groups. Thus, although probiotics were well-tolerated when administered with SIV/HIV vaccination, vaccine-specific responses were not significantly enhanced. Additional work will be necessary to develop more effective strategies of microbiome modulation in order to enhance mucosal vaccine immunogenicity and improve protective immune responses.
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Details
- Title
- Effects of persistent modulation of intestinal microbiota on SIV/HIV vaccination in rhesus macaques
- Creators
- Nichole R Klatt - University of WashingtonCourtney Broedlow - University of Minnesota Twin CitiesJessica M Osborn - University of WashingtonAndrew T Gustin - University of WashingtonSandra Dross - University of WashingtonMegan A O'Connor - University of WashingtonErnesto Coronado - University of WashingtonPhilip Barnette - Oregon National Primate Research CenterTiffany Hensley-McBain - University of WashingtonAlexander S Zevin - University of WashingtonRoshell Muir - Drexel UniversityAlexander Roederer - Washington National Primate Research Center, University of Washington, Seattle, WA, USASolomon Wangari - University of WashingtonNaoto Iwayama - University of WashingtonChul Y Ahrens - University of WashingtonJeremy Smedley - Oregon Health & Science UniversityCassandra Moats - Oregon Health & Science UniversityRebecca M Lynch - George Washington UniversityElias K Haddad - Drexel UniversityNancy L Haigwood - Oregon National Primate Research CenterDeborah H Fuller - University of WashingtonJennifer A Manuzak - Tulane University
- Publication Details
- npj vaccines, v 6(1), pp 34-34
- Publisher
- Springer Nature
- Grant note
- K01OD024876 / U.S. Department of Health & Human Services | NIH | NIH Office of the Director (OD) P51 OD011104 / NIH HHS K01 OD024876 / NIH HHS R01 AI120712 / NIAID NIH HHS R01AI120712 / U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) P51 OD011092 / NIH HHS P51 OD010425 / NIH HHS T32 AI007140 / NIAID NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Infectious Diseases (and HIV Medicine)
- Web of Science ID
- WOS:000627784200001
- Scopus ID
- 2-s2.0-85102435080
- Other Identifier
- 991019167900704721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Immunology
- Medicine, Research & Experimental