Journal article
Effects of thyroidectomy, parathyroidectomy and lithium on circadian wheelrunning in rats
Physiology & behavior, v 42(1)
1988
PMID: 3387475
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Circadian rhythms and levels of wheelrunning were studied in thyroidectomized, parathyroidectomized, thyro-parathyroidectomized, and sham-operated male rats. Animals were entrained to a 12:12 light:dark schedule, then exposed to constant dim red illumination, and then given a diet containing lithium. Under constant condtions, free-running circadian activity rhythms were shorter, and levels of activity were greater, in thyroidectomized and thyroparathyroidectomized animals. Lithium reversed these effects, lengthening free-running circadian periods in all groups, with a greater reduction of activity observed in animals with thyroids removed. Parathyroidectomy had no clear effects. Since lithium slowed circadian rhythms and reduced activity even in the absence of intact thyroid or parathyroid glands, these effects may have been due to the action of lithium at some other site. The same may be true of other thyroid suppressors reported to affect circadian rhythms. These findings may be relevant to the biological substrates of major affective disorders in humans, which have been associated with abnormalities of thyroid function, abnormally short circadian rhythms, abnormal activity levels, and responsiveness to lithium therapy.
Metrics
Details
- Title
- Effects of thyroidectomy, parathyroidectomy and lithium on circadian wheelrunning in rats
- Creators
- Jonathan Schull - Haverford CollegeDonald L. McEachron - University of PennsylvaniaNorman T. Adler - University of PennsylvaniaLizabeth Fiedler - Haverford CollegeJonathan Horvitz - Haverford CollegeAlison Noyes - Haverford CollegeMartha Olson - Haverford CollegeJonathan Shack - Haverford College
- Publication Details
- Physiology & behavior, v 42(1)
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Psychiatry; School of Biomedical Engineering, Science, and Health Systems; Drexel University
- Web of Science ID
- WOS:A1988L787200006
- Scopus ID
- 2-s2.0-0023930381
- Other Identifier
- 991019323782304721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Behavioral Sciences
- Psychology, Biological