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Journal article
Effects of thyroxine and thyroparathyroidectomy on circadian wheel running in rats
Pharmacology, biochemistry and behavior, v 46(1), pp 243-249
1993
PMID: 8255918
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Thyroparathyroidectomized (TPX) and thyroidectomized male rats display shorter free-running activity periods and enhanced activity levels. These experiments were designed to determine whether this effect is due to the loss of thyroid hormones. The running wheel activity of 36 male rats, 19 TPX and 17 sham operated, was studied. The animals were kept in constant conditions for 7 weeks to obtain baseline data. Half the rats were then injected SC with capsules containing T4, while the other half were injected with blanks. All animals were then allowed to free-run undisturbed for another 8–9 weeks. TPX rats displayed significantly shorter baseline periods (average difference: 0.26 h) and heightened activity. Thyroxine treatment significantly lengthened TPX animals' cycles (average increase: 0.28 h) but did not affect intact rats' circadian rhythms. Thyroxine did, however, significantly decreased the activity levels of both TPX and sham-operated rats. These findings indicate that changes in TPX rats' activity cycles are caused by a reduction in thyroid hormones and that thyroxine acts on activity rhythms and levels by different mechanisms.
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Details
- Title
- Effects of thyroxine and thyroparathyroidectomy on circadian wheel running in rats
- Creators
- Donald L. McEachron - University of PennsylvaniaChristina L. Lauchlan - University of PennsylvaniaDeborah E. Midgley - University of Pennsylvania
- Publication Details
- Pharmacology, biochemistry and behavior, v 46(1), pp 243-249
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems; Drexel University
- Web of Science ID
- WOS:A1993LY41300040
- Scopus ID
- 2-s2.0-0027448518
- Other Identifier
- 991019323763204721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Behavioral Sciences
- Neurosciences
- Pharmacology & Pharmacy