Journal article
Effects of tri-Calciphor (trimer of 16, 16-dimethyl-15-dehydroprostaglandin B1) on glucose metabolism in liver cells
Biochemical and biophysical research communications, v 201(3), pp 1457-1463
30 Jun 1994
PMID: 8024591
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Phosphorylase activity of isolated rat liver cells was increased about 2-fold on addition of tri-Calciphor (trimer of 16, 16-dimethyl-15-dehydroprostaglandin B1), epinephrine or the Ca2+ ionophore A23187, in all cases presumably due to an increase in cytosolic Ca2+. Extracellular Ca2+ was required with A23187, but not with either tri-Calciphor or epinephrine. Tri-Calciphor, however, did not stimulate a sustained release of glucose from hepatocytes as compared to the other Ca2+ mobilizing agents, even at concentrations 10-fold higher than that required to stimulate the phosphorylase activity. Tri-Calciphor did not alter the glucose release by epinephrine. It is concluded that tri-Calciphor can alter cytosolic Ca2+, but that its mechanism of action is more complex than that of a simple Ca2+ ionophore.
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Details
- Title
- Effects of tri-Calciphor (trimer of 16, 16-dimethyl-15-dehydroprostaglandin B1) on glucose metabolism in liver cells
- Creators
- R Villalobos-MolinaT M Devlin - Hahnemann University Hospital
- Publication Details
- Biochemical and biophysical research communications, v 201(3), pp 1457-1463
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biochemistry and Molecular Biology
- Web of Science ID
- WOS:A1994NU97700056
- Scopus ID
- 2-s2.0-0028030374
- Other Identifier
- 991019183918604721
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- Web of Science research areas
- Biochemistry & Molecular Biology
- Biophysics