Journal article
Effects of underwater sound exposure on neurological function and brain histology
Ultrasound in medicine & biology, v 28(7), pp 965-973
2002
PMID: 12208341
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
To evaluate the safety of sonar exposure from a neurological perspective, the vulnerability of the central nervous system to underwater exposure with high-intensity, low-frequency sound (HI-LFS) was experimentally examined. Physiological, behavioral and histological parameters were measured in anesthetized, ventilated rats exposed to brief (5 min), underwater HI-LFS. Exposure to 180 dB sound pressure level (SPL) re 1 μPa at 150 Hz (
n = 9) did not alter acute cardiovascular physiology (arterial blood pH, pO
2, pCO
2, heart rate, or mean arterial blood pressure) from that found in controls (
n = 11). Rats exposed to either 180 dB SPL re 1 μPa at 150 Hz (
n = 12) or 194 dB SPL re 1 μPa at 250 Hz (
n = 12) exhibited normal cognitive function at 8 and 9 days after sound exposure. Evaluation of neurological motor function revealed a minor deficit 7 days after 180 dB SPL/150 Hz exposure that resolved by 14 days, and no deficits after 194 dB SPL/250 Hz exposure. No overt histological damage was detected in any group. These data suggest that underwater HI-LFS exposure may cause transient, mild motor dysfunction.
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Details
- Title
- Effects of underwater sound exposure on neurological function and brain histology
- Creators
- Helmut L Laurer - Department of Neurosurgery, University of Pennsylvania School of Medicine, Philadelphia, PA, USAAndrew N Ritting - Department of Neurosurgery, University of Pennsylvania School of Medicine, Philadelphia, PA, USAAndrew B Russ - Department of Neurosurgery, University of Pennsylvania School of Medicine, Philadelphia, PA, USAFlorence M Bareyre - Department of Neurosurgery, University of Pennsylvania School of Medicine, Philadelphia, PA, USARamesh Raghupathi - Department of Neurosurgery, University of Pennsylvania School of Medicine, Philadelphia, PA, USAKathryn E Saatman - Department of Neurosurgery, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
- Publication Details
- Ultrasound in medicine & biology, v 28(7), pp 965-973
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000177650800018
- Scopus ID
- 2-s2.0-0036658652
- Other Identifier
- 991014877998804721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Acoustics
- Radiology, Nuclear Medicine & Medical Imaging