Journal article
Effects of venous pressure on coronary circulation and intramyocardial fluid mechanics
American journal of physiology. Heart and circulatory physiology, v 267(3), pp H1002-H1009
01 Sep 1994
PMID: 8092266
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
This investigation examined the interaction between right heart pressure (RHP), coronary perfusion pressure (CPP), intramyocardial tissue pressure (IMP), and coronary flow mechanics, including partitioning of coronary effluent in the isolated Krebs-Henseleit perfused rabbit heart. The major new finding was a parallel shift in the IMP-inflow relationship to a higher tissue pressure level in response to an increase in RHP. Accompanying the rise in RHP from 0 to 15 and 25 mmHg, IMP at zero coronary inflow in the beating (and arrested) heart increased from 5.8 +/- 1.0 (7.7 +/- 1.2) to 16.3 +/- 1.2 (17.9 +/- 1.3) and 28.6 +/- 1.7 (26.4 +/- 2.0) mmHg, respectively. A concomitant parallel shift in the CPP-inflow relation to higher pressures was consistently observed. The fraction of total coronary flow drained by the right heart was not constant. A higher partition of coronary outflow to the left heart (7.8 +/- 3.8, 34.3 +/- 3.0, and 47.9 +/- 4.3%, respectively) accompanied the increase in RHP. Intramyocardial partitioning of coronary outflow pathways mediates the effects of venous pressure modulation on coronary circulation. The interaction between coronary venous pressure and the extravascular environment modifies the effective back pressure to arterial inflow.
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Details
- Title
- Effects of venous pressure on coronary circulation and intramyocardial fluid mechanics
- Creators
- I Izrailtyan - Department of Cardiothoracic Surgery and Medicine, LikoffCardiovascular Institute, Hahnemann University, Philadelphia, Pennsylvania19102-1192H. F Frasch - Department of Cardiothoracic Surgery and Medicine, LikoffCardiovascular Institute, Hahnemann University, Philadelphia, Pennsylvania19102-1192J. Y Kresh - Department of Cardiothoracic Surgery and Medicine, LikoffCardiovascular Institute, Hahnemann University, Philadelphia, Pennsylvania19102-1192
- Publication Details
- American journal of physiology. Heart and circulatory physiology, v 267(3), pp H1002-H1009
- Publisher
- American Physiological Society (APS)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- [Retired Faculty]
- Web of Science ID
- WOS:A1994PH38300019
- Scopus ID
- 2-s2.0-0028145906
- Other Identifier
- 991014878058904721
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- Web of Science research areas
- Physiology