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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Effects of visceral adipose tissue reduction on CVD risk factors independent of weight loss: The Look AHEAD study
Endocrine research, v 42(2)
03 Apr 2017
PMID: 27351077
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Objectives: To determine if the reduction of visceral adipose tissue (VAT) volume by lifestyle intervention improved risk factors for cardiovascular disease (CVD) independent of weight loss amount. Design: Ancillary study of randomized-controlled trial. Setting: Data analysis using multivariable regression models. Participants: Participants of the Look AHEAD (Action for HEAlth in Diabetes) Fatty Liver Ancillary Study. Main outcome measures: Correlations between changes in VAT and in CVD risk factors, while adjusting for weight loss and treatment (intensive lifestyle intervention [ILI] vs. diabetes support and education [DSE]). Results: Of 100 participants analyzed, 52% were women, and 36% were black, with a mean age of 61.1 years. In the DSE group, mean weight and VAT changed by 0.1 % (p=0.90) and 4.3% (p=0.39), respectively. In the ILI group, mean weight and VAT decreased by 8.0% (p<0.001) and 7.7% (p=0.01), respectively. Across both groups, mean weight decreased by 3.6% (p<0.001), and mean VAT decreased by 1.2% (p=0.22); the decrease in VAT was correlated with the increase in HDL-cholesterol (HDL-C; R=−0.37; p=0.03). There were no correlations between changes in VAT and blood pressure, triglycerides, LDL-C, glucose, or HbA1c. After adjusting for age, race, gender, baseline metabolic values, fitness, and treatment group, changes in HDL-C were not associated with changes in VAT, while weight changes were independently associated with decrease in glucose, HbA1c, and increase in HDL-C. Conclusions: VAT reduction was not correlated with improvements of CVD risk factors in a sample of overweight and obese adults with type 2 diabetes after adjusting for weight loss.
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Details
- Title
- Effects of visceral adipose tissue reduction on CVD risk factors independent of weight loss: The Look AHEAD study
- Creators
- Anawin Sanguankeo - Siriraj HospitalMariana Lazo - Johns Hopkins MedicineSikarin Upala - Mahidol UniversityFrederick L. Brancati - Johns Hopkins UniversitySusanne Bonekamp - Johns Hopkins UniversityHenry J. Pownall - Cornell CollegeAshok Balasubramanyam - Baylor College of MedicineJeanne M. Clark - Johns Hopkins University School of MedicineLook AHEAD Res Grp
- Publication Details
- Endocrine research, v 42(2)
- Publisher
- Taylor & Francis
- Grant note
- M01-RR-00052 / Johns Hopkins University (10.13039/100007880) U01-DK-57149 / National Institute of Diabetes and Digestive and Kidney Diseases (10.13039/100000062) R01-DK-060427 / National Institutes of Health (10.13039/100000002)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Urban Health Collaborative
- Web of Science ID
- WOS:000399655700002
- Scopus ID
- 2-s2.0-84976388643
- Other Identifier
- 991020550344104721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Endocrinology & Metabolism