Journal article
Efferent compared to afferent neural substrates of the vergence eye movement system evoked via fMRI
Frontiers in neuroscience, v 18, 1497326
08 Jan 2025
PMID: 39844855
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Introduction The vergence neural system was stimulated to dissect the afferent and efferent components of symmetrical vergence eye movement step responses. The hypothesis tested was whether the afferent regions of interest would differ from the efferent regions to serve as comparative data for future clinical patient population studies.Methods Thirty binocularly normal participants participated in an oculomotor symmetrical vergence step block task within a functional MRI experiment compared to a similar sensory task where the participants did not elicit vergence eye movements.Results For the oculomotor vergence task, functional activation was observed within the parietal eye field, supplemental eye field, frontal eye field, and cerebellar vermis, and activation in these regions was significantly diminished during the sensory task. Differences between the afferent sensory and efferent oculomotor experiments were also observed within the visual cortex.Discussion Differences between the vergence oculomotor and sensory tasks provide a protocol to delineate the afferent and efferent portion of the vergence neural circuit. Implications with clinical populations and future therapeutic intervention studies are discussed.
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Details
- Title
- Efferent compared to afferent neural substrates of the vergence eye movement system evoked via fMRI
- Creators
- Ayushi Sangoi - New Jersey Institute of TechnologyFarzin Hajebrahimi - New Jersey Institute of TechnologySuril Gohel - Rutgers, The State University of New JerseyMitchell Scheiman - Drexel University Elkins Park CampusTara L. Alvarez (Corresponding Author) - New Jersey Institute of Technology
- Publication Details
- Frontiers in neuroscience, v 18, 1497326
- Publisher
- Frontiers Media Sa
- Number of pages
- 13
- Grant note
- NSF GRFP; National Science Foundation (NSF); NSF - Office of the Director (OD) NEI R01EY023261 / National Eye Institute of the National Institutes of Health, Department of Health and Human Services, Bethesda
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pennsylvania College of Optometry (PCO)
- Web of Science ID
- WOS:001401285200001
- Scopus ID
- 2-s2.0-85215417351
- Other Identifier
- 991022202504004721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Neurosciences