Journal article
Efficacy and Tolerability of Lacosamide in the Treatment of Children With Refractory Generalized Epilepsy
Journal of child neurology, v 31(7), pp 925-928
Jun 2016
PMID: 26887412
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Lacosamide is FDA-approved in patients 17 years or older with partial-onset epilepsy. We evaluated the efficacy and tolerability of lacosamide in children with refractory generalized epilepsy. We retrospectively reviewed records of 21 children with refractory generalized epilepsy treated with lacosamide in our institution from 2009-2013 divided into 2 subgroups- I, Lennox-Gastaut Syndrome, and II, other generalized epilepsies. Efficacy was defined as seizure freedom or ≥50% seizure reduction. Descriptive data analysis including seizure freedom was compared using c(2) analysis. There were eleven females and ten males with a mean age, of 11.9 years. Five patients became seizure free, nine had ≥50% seizure reduction, and seven had no response. Group I: seven had ≥50% improvement, one did not respond. Group II: five became seizure free, two had ≥50% improvement, five had no response. Lacosamide is effective and well tolerated in children with refractory generalized epilepsy particularly patients with Lennox-Gastaut Syndrome.
Metrics
Details
- Title
- Efficacy and Tolerability of Lacosamide in the Treatment of Children With Refractory Generalized Epilepsy
- Creators
- Chandrabhaga Miskin - St. Christopher's Hospital for ChildrenDivya S Khurana - St. Christopher's Hospital for ChildrenIgnacio Valencia - St. Christopher's Hospital for ChildrenAgustin Legido - St. Christopher's Hospital for ChildrenDaphne M Hasbani - St. Christopher's Hospital for ChildrenKaren S Carvalho - St. Christopher's Hospital for Children
- Publication Details
- Journal of child neurology, v 31(7), pp 925-928
- Publisher
- Sage
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics
- Web of Science ID
- WOS:000376264800018
- Scopus ID
- 2-s2.0-84969285679
- Other Identifier
- 991019168709404721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Clinical Neurology
- Pediatrics