Journal article
Efficacy and Tolerability of Topiramate in Pediatric Migraine
Pediatric neurology, v 41(3), pp 167-170
01 Sep 2009
PMID: 19664530
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Z About 5-10% of school-age children manifest migraine headaches. Treatment options for pediatric migraine are limited. Topiramate is approved for migraine prophylaxis in adults, but its use in children is limited. We retrospectively reviewed the records of 37 patients, i.e., 22 (60%) girls and =15 (40%) boys (mean age, 14 years; range, 7.3-20.5 years), diagnosed with migraine without aura in 30 (81%), with aura in four (11%), and abdominal, ophthalmoplegic, and catamenial in one each. The mean follow-up was 12 +/- 5 months standard deviation (S.D.). Clinical response was qualified as excellent, good, no change, or worse. Numbers of headaches per month were 15 +/- 7 S.D. prior to treatment and 3 +/- 3.4 S.D. (P<0.001) after treatment. An excellent or good response (>50% migraine reduction) was attained in 28 patients (76%). Ten (27%) patients exhibited adverse effects. Patients taking >2 mg/kg/day were more likely to demonstrate side effects. The mean dose for patients without adverse effects was 1.27 +/- 0.7 mg/kg/day S.D. Those who reported adverse effects were taking a mean dose of 2.8 +/- 1.5 mg/kg/day S.D. This study demonstrated that topiramate is an effective, safe alternative for the prophylaxis of pediatric migraine. An acceptable risk/benefit maintenance dose was <= 2 mg/kg/day. (C) 2009 by Elsevier Inc. All rights reserved.
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Details
- Title
- Efficacy and Tolerability of Topiramate in Pediatric Migraine
- Creators
- Marcos J. Cruz - St. Christopher's Hospital for ChildrenIgnacio Valencia - St. Christopher's Hospital for ChildrenAgustin Legido - St. Christopher's Hospital for ChildrenSanjeev V. Kothare - St. Christopher's Hospital for ChildrenDivya S. Khurana - St. Christopher's Hospital for ChildrenSabrina Yum - St. Christopher's Hospital for ChildrenHuntley H. Hardison - St. Christopher's Hospital for ChildrenJoseph J. Melvin - St. Christopher's Hospital for ChildrenHarold G. Marks - St. Christopher's Hospital for Children
- Publication Details
- Pediatric neurology, v 41(3), pp 167-170
- Publisher
- Elsevier
- Number of pages
- 4
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics
- Web of Science ID
- WOS:000268866200002
- Scopus ID
- 2-s2.0-67949086857
- Other Identifier
- 991019168767104721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Clinical Neurology
- Pediatrics