Journal article
Efficacy of bronchial thermoplasty in a patient panel with uncontrolled severe persistent asthma
The Journal of asthma, v 61(8), pp 867-875
02 Aug 2024
PMID: 38294702
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background: Bronchial thermoplasty (BT) is an approved procedure to manage uncontrolled severe persistent asthma. Many insurance providers are reluctant to pay for BT without proven benefit among their specific patient panel. Objective: Determine if BT is effective in a panel patient panel with uncontrolled severe persistent asthma. Study design and methods: This was an unblinded prospective study of adult subjects with uncontrolled severe persistent asthma who underwent BT. Outcomes were assessed at baseline and then 3-, 6-, 12-, 18- and 24-months post-BT. The primary metric was an improved Asthma Quality of Life Questionnaire (AQLQ) score. Other metrics included improved Asthma Control Test (ACT), peak expiratory flow rates (PEFR), spirometry, fractional excretion of nitric oxide (FeNO), number of unscheduled medical visits, and lost days of work/activity. Respiratory adverse events were assessed during the BT treatment period and at each post-BT visit. Results: Twenty-nine subjects completed the study; the median interquartile range (IQR) age was 47 (42-61), and the majority were female (69%), white (93%), and non-Hispanic (90%). After BT, mean (+/- std) AQLQ scores improved by 1.6(+/- 1.1) at 3 months (p < 0.0001), 1.6(&+/- 1.2) at 6 months (p < 0.0001), 1.4(+/- 1.0) at 12 months (p < 0.0001), 1.8(+/- 1.1) at 18 months (p < 0.0001), and 1.6 (+/- 1.5) at 24 months (p < 0.0001). There were significant improvements in ACT, PEFR, unscheduled medical visits and lost days of work and activity. Spirometry and FeNO metrics were unchanged. The average cost for subjects completing all 3 BT procedures was approximately $15,000. Conclusion: BT is an effective adjunctive therapeutic modality in subjects with uncontrolled severe persistent asthma.
Metrics
Details
- Title
- Efficacy of bronchial thermoplasty in a patient panel with uncontrolled severe persistent asthma
- Creators
- Antonios Zikos - Allegheny General HospitalMarvin Balaan - Allegheny General HospitalEmily Hobart - Highmark Blue Cross Blue ShieldSandeep Bansal - Penn Highlands HealthcareRihab Saeed - Allegheny General HospitalTariq Cheema - Allegheny General HospitalDeborah Gentile - Saint Francis University
- Publication Details
- The Journal of asthma, v 61(8), pp 867-875
- Publisher
- Taylor & Francis
- Number of pages
- 9
- Grant note
- Highmark Health (Pittsburgh, PA, United States of America)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- General Internal Medicine
- Web of Science ID
- WOS:001158098900001
- Scopus ID
- 2-s2.0-85184450282
- Other Identifier
- 991022083950404721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Allergy
- Respiratory System