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Journal article
Eggshell membrane in the treatment of pain and stiffness from osteoarthritis of the knee: a randomized, multicenter, double-blind, placebo-controlled clinical study
Clinical rheumatology, v 28(8), pp 907-914
01 Aug 2009
PMID: 19340512
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Natural Eggshell Membrane (NEMA (R)) is a new novel dietary supplement that contains naturally occurring glycosaminoglycans and proteins essential for maintaining healthy articular cartilage and the surrounding synovium. The randomized, multicenter, double-blind, placebo-controlled Osteoarthritis Pain Treatment Incorporating NEMA (R) clinical study was conducted to evaluate the efficacy and safety of NEMA (R) as a treatment for pain and stiffness associated with osteoarthritis of the knee. Sixty-seven patients were randomly assigned to receive either oral NEMA (R) 500 mg (n = 34) or placebo (n = 33) daily for 8 weeks. The primary endpoint was the change in overall Western Ontario and McMasters Universities (WOMAC) Osteoarthritis Index as well as pain, stiffness, and function WOMAC subscales measured at 10, 30, and 60 days. The clinical assessment was performed on the intent-to-treat population. Supplementation with NEMA (R) produced an absolute rate of response that was statistically significant (up to 26.6%) versus placebo at all time points for both pain and stiffness, but was not significantly improved for function and overall WOMAC scores, although trending toward improvement. Rapid responses were seen for mean pain subscores (15.9% reduction, P = 0.036) and mean stiffness subscores (12.8% reduction, P = 0.024) occurring after only 10 days of supplementation. There were no serious adverse events reported during the study and the treatment was reported to be well tolerated by study participants. Natural Eggshell Membrane (NEMA (R)) is an effective and safe option for the treatment of pain and stiffness associated with knee osteoarthritis. Supplementation with NEMA (R), 500 mg taken once daily, significantly reduced both joint pain and stiffness compared to placebo at 10, 30, and 60 days. The Clinical Trial Registration number for this study is NCT00750477.
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Details
- Title
- Eggshell membrane in the treatment of pain and stiffness from osteoarthritis of the knee: a randomized, multicenter, double-blind, placebo-controlled clinical study
- Creators
- Kevin J. Ruff - ESM Technol LLC, Carthage, MO 64836 USAAnne Winkler - St. John's HospitalRobert W. Jackson - Reg Specialty Clin, Kirksville, MO 63501 USADale P. DeVore - Membrell LLC, Carthage, MO 64836 USABarry W. Ritz - Drexel University
- Publication Details
- Clinical rheumatology, v 28(8), pp 907-914
- Publisher
- Springer Nature
- Number of pages
- 8
- Grant note
- ESM Technologies, LLC
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Bioscience and Biotechnology [Historical]
- Web of Science ID
- WOS:000268102100006
- Scopus ID
- 2-s2.0-67849118767
- Other Identifier
- 991021883115704721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Rheumatology