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Journal article
Elastography in Chronic Liver Disease: Modalities, Techniques, Limitations, and Future Directions
Radiographics, v 36(7), pp 1987-2006
01 Nov 2016
PMID: 27689833
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Chronic liver disease has multiple causes, many of which are increasing in prevalence. The final common pathway of chronic liver disease is tissue destruction and attempted regeneration, a pathway that triggers fibrosis and eventual cirrhosis. Assessment of fibrosis is important not only for diagnosis but also for management, prognostic evaluation, and follow-up of patients with chronic liver disease. Although liver biopsy has traditionally been considered the reference standard for assessment of liver fibrosis, noninvasive techniques are the emerging focus in this field. Ultrasound-based elastography and magnetic resonance (MR) elastography are gaining popularity as the modalities of choice for quantifying hepatic fibrosis. These techniques have been proven superior to conventional cross-sectional imaging for evaluation of fibrosis, especially in the precirrhotic stages. Moreover, elastography has added utility in the follow-up of previously diagnosed fibrosis, the assessment of treatment response, evaluation for the presence of portal hypertension (spleen elastography), and evaluation of patients with unexplained portal hypertension. In this article, a brief overview is provided of chronic liver disease and the tools used for its diagnosis. Ultrasound-based elastography and MR elastography are explored in depth, including a brief glimpse into the evolution of elastography. Elastography is based on the principle of measuring tissue response to a known mechanical stimulus. Specific elastographic techniques used to exploit this principle include MR elastography and ultrasonography-based static or quasistatic strain imaging, one-dimensional transient elastography, point shear-wave elastography, and supersonic shear-wave elastography. The advantages, limitations, and pitfalls of each modality are emphasized. (C) RSNA, 2016
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Details
- Title
- Elastography in Chronic Liver Disease: Modalities, Techniques, Limitations, and Future Directions
- Creators
- Aparna Srinivasa Babu - Catholic Medical CenterMichael L. Wells - Mayo ClinicOleg M. Teytelboym - Catholic Medical CenterJustin E. Mackey - Catholic Medical CenterFrank H. Miller - Northwestern UniversityBenjamin M. Yeh - University of California, San FranciscoRichard L. Ehman - Mayo ClinicSudhakar K. Venkatesh - Mayo Clinic
- Publication Details
- Radiographics, v 36(7), pp 1987-2006
- Publisher
- Radiological Soc North America
- Number of pages
- 20
- Grant note
- Cum Laude and Certificate of Merit awards R37EB001981 / NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Biomedical Imaging & Bioengineering (NIBIB)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Radiology (Radiologic Sciences); Medicine (Graduate)
- Web of Science ID
- WOS:000391424800004
- Scopus ID
- 2-s2.0-84994908957
- Other Identifier
- 991021897585404721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Radiology, Nuclear Medicine & Medical Imaging