Journal article
Electrical stimulation of sympathetic nerves increases the concentration of cyclic AMP in rat pineal gland
Proceedings of the National Academy of Sciences - PNAS, v 78(11), pp 7176-7179
01 Nov 1981
PMID: 6273917
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Electrical stimulation of the superior cervical ganglia causes a rapid increase in the concentration of cyclic AMP in the pineal gland of rats. This effect is dependent upon the frequency, voltage, and duration of the stimulus and is markedly potentiated by pretreating the animals with desmethylimipramine. The increase in cyclic AMP is blocked by prior treatment of the rats with reserpine, bretylium, or propanolol but not with phentolamine. These results provide direct evidence that electrical stimulation of sympathetic nerves increases cyclic AMP in a target organ through the release of norepinephrine from presynaptic terminals acting on postsynaptic beta-adrenergic receptors.
Metrics
Details
- Title
- Electrical stimulation of sympathetic nerves increases the concentration of cyclic AMP in rat pineal gland
- Creators
- W E HeydornA FrazerB Weiss
- Publication Details
- Proceedings of the National Academy of Sciences - PNAS, v 78(11), pp 7176-7179
- Publisher
- PNAS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:A1981MQ92600123
- Scopus ID
- 2-s2.0-0019640623
- Other Identifier
- 991019183988704721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Biology