Journal article
Electrophysiologic testing in patients at high risk for sudden cardiac death. I. nonsustained ventricular tachycardia and abnormal ventricular function
Journal of the American College of Cardiology, v 6(1), pp 31-39
Jul 1985
PMID: 4008786
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Abstract
Nonsustained ventricular tachycardia, although usually asymptomatic, is associated with a high risk of sudden cardiac death in patients with depressed left ventricular function. To test the vulnerability of such patients to symptomatic and potentially life-threatening arrhythmias, complete electrophysiologic studies were performed in 58 patients with clinically documented non-sustained ventricular tachycardia (≥three complexes but <15 seconds of self-terminating ventricular tachycardia by 24 hour ambulatory electrocardiographic [Holter] or telemetric monitoring) and abnormal left ventricular function (ejection fraction <50% by radionuclide angiography). All patients had nonsustained ventricular tachycardia in the absence of antiarrhythmic drugs, acute ischemia, long QT syndrome, recent infarction or electrolyte abnormalities. The stimulation protocol for each patient included the introduction of single, double and triple ventricular extrastimuli at three cycle lengths (sinus, 600 and 450 ms) and two right ventricular sites (apex and outflow tract). A sustained ventricular tachyarrhythmia was induced in 23 patients (40%) and a nonsustained ventricular tachycardia in 14 patients (24%). Induction of sustained tachycardia correlated with the presence of akinesia or aneurysm, or both, by radionuclide angiography, but not with ejection fraction or presence or absence of coronary artery disease.
These results indicate that: 1) patients with clinical nonsustained ventricular tachycardia and chronic left ventricular dysfunction have a high incidence of inducible sustained ventricular tachycardia or ventricular fibrillation; and 2) electrophysiologic testing may allow further substratification of risk of sudden cardiac death in high risk patients with nonsustained ventricular tachycardia.
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Details
- Title
- Electrophysiologic testing in patients at high risk for sudden cardiac death. I. nonsustained ventricular tachycardia and abnormal ventricular function
- Creators
- Scott R. Spielman - Cardiovascular Institute of the SouthAllan M. Greenspan - Cardiovascular Institute of the SouthHarold R. Kay - Cardiovascular Institute of the SouthKathy F. Discigil - Cardiovascular Institute of the SouthCharles R. Webb - Cardiovascular Institute of the SouthNeil M. Sokoloff - Cardiovascular Institute of the SouthAlan P. Rae - Cardiovascular Institute of the SouthJoel Morganroth - Cardiovascular Institute of the SouthLeonard N. Horowitz - Cardiovascular Institute of the South
- Publication Details
- Journal of the American College of Cardiology, v 6(1), pp 31-39
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine
- Web of Science ID
- WOS:A1985ALK9200005
- Scopus ID
- 2-s2.0-0021864654
- Other Identifier
- 991019339575604721
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- Web of Science research areas
- Cardiac & Cardiovascular Systems