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Journal article
Electrophysiological actions of VIP in rat somatosensory cortex
Peptides (New York, N.Y. : 1980), v 12(4), pp 715-721
1991
PMID: 1788134
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Abstract
Electrophysiological and biochemical studies suggest that VIP may exert a facilitating action in the neocortical local circuitry. In the present study, we examined the actions of VIP and VIP + norepinephrine (NE) on somatosensory cortical neuron responses to direct application of the putative transmitters acetylcholine (ACh) and gamma-aminobutyric acid (GABA). Spontaneous and transmitter-induced discharges of cortical neurons from halothane-anesthetized rats were monitored before, during and after VIP, NE and VIP + NE iontophoresis. In 57 VIP-sensitive cells tested, VIP application (5–70 nA) increased (
n = 18
), decreased (
n = 36
) or had biphasic actions (
n = 3
) on background firing rate. In a group of 20 neurons tested for NE + VIP, the combined effect of both peptide and bioamine was predominantly (70%) inhibitory. On the other hand, inhibitory and excitatory responses of cortical neurons to GABA (11 of 15 cases) and ACh (10 of 18 cases), respectively, were enhanced during VIP iontophoresis. Concomitant application of VIP and NE produced additive (
n = 2
) or more than additive (
n = 3
) enhancing effects on GABA inhibition. NE administration reversed or enhanced further VIP modulatory actions on ACh-induced excitation. These findings provide electrophysiological evidence that NE and VIP afferents may exert convergent influences on cortical neuronal responses to afferent synaptic inputs such that modulatory actions are anatomically focused within the cortex.
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Details
- Title
- Electrophysiological actions of VIP in rat somatosensory cortex
- Creators
- Francis M Sessler - Department of Physiology and Biophysics, Hahnemann University, Philadelphia, PA 19102-1192 USASteve M Grady - Department of Physiology and Biophysics, Hahnemann University, Philadelphia, PA 19102-1192 USABarry D Waterhouse - Department of Physiology and Biophysics, Hahnemann University, Philadelphia, PA 19102-1192 USAHylan C Moises - Department of Physiology, University of Michigan, Medical School, Ann Arbor, MI 48109 USA
- Publication Details
- Peptides (New York, N.Y. : 1980), v 12(4), pp 715-721
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy; [Retired Faculty]
- Web of Science ID
- WOS:A1991GG17500006
- Scopus ID
- 2-s2.0-0025878528
- Other Identifier
- 991014878470804721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Biochemistry & Molecular Biology
- Endocrinology & Metabolism
- Pharmacology & Pharmacy