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Electrophysiology of esmolol
Journal article   Peer reviewed

Electrophysiology of esmolol

Allan M. Greenspan, Scott R. Spielman, Leonard N. Horowitz, Sheila Senior, James Steck and Atul Laddu
The American journal of cardiology, v 56(11), pp F19-F26
1985
DOI: https://doi.org/10.1016/0002-9149(85)90912-9
PMID: 2864844
Featured in Collection :   UN Sustainable Development Goals @ Drexel

Abstract

The electrophysiologic characteristics of esmolol were studied in 14 patients. Ten men and 4 women, mean age 57 years, were electrophysiologically evaluated at baseline, and also at 4 to 8 minutes after the administration of a maintenance infusion of esmolol. Plasma samples for esmolol blood levels were drawn at 10 minutes of the maintenance infusion, at the end of the maintenance infusion and 30 minutes after the maintenance infusion was discontinued. Results of this study showed that esmolol has typical β-blocker electrophysiologic effects. Its major action was on sinus node function; it prolonged this basic sinus cycle length but had no significant effect on intrinsic automaticity as reflected by the corrected sinus node recovery time and sinoatrial conduction. Direct effects on atrioventricular (AV) nodal function were reflected by effects on AV nodal conduction and refractoriness. There was no direct effect on atrial function and, as expected, no effect on His-Purkinje or ventricular function. The intensity of esmolol's electrophysiologic effects on sinus mode function, AV nodal conduction and AH interval is comparable to those of other β blockers.

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19 citations in Web of Science
23 citations in Scopus

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Web of Science research areas
Cardiac & Cardiovascular Systems
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