Journal article
Elemene, the essential oil of Curcuma wenyujin, inhibits osteogenic differentiation in ankylosing spondylitis
Joint, bone, spine : revue du rhumatisme, v 82(2), pp 100-103
2014
PMID: 25636898
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
To explore the effects of Elemene, the essential oil of Curcuma wenyujin, on Bone morphogenetic protein/drosophila mothers against decapentaplegic proteins (BMP/SMADs) signal pathway in ankylosing spondylitis (AS) fibroblasts.
Hip joint capsules were obtained from AS patients (n=10) receiving total hip replacement. Healthy hip joint capsules from patients with hip fracture (n=10) receiving surgery were included as a control. Primary fibroblast cell lines were established from these tissue samples. Fibroblasts were incubated with Elemene for 48hours. The protein expression was detected by Western blot. The mRNA expression was detected by real-time fluorescent quantitative polymerase chain reaction (PCR).
The results showed that the expression of proteins including SMAD1, pSMAD1, SMAD4 and Runt-related transcription factor 2 (RUNX2), and mRNA of RUNX2, which were over-expressed in AS fibroblasts were decreased in the AS fibroblasts cultured in medium with Elemene.
Ele could have a hand in anti-osteogenic differentiation of AS fibroblasts by inhibiting the BMP/SMADs signal pathway and subsequently blocking expression of ossification marker genes RUNX2 that initiate the osteogenic differentiation.
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Details
- Title
- Elemene, the essential oil of Curcuma wenyujin, inhibits osteogenic differentiation in ankylosing spondylitis
- Creators
- Ying-yan Zhou - Guangzhou University of Chinese MedicineHong-xiao Liu - Guang’anmen HospitalNan Jiang - Guang’anmen HospitalXing-hua Feng - Guang’anmen HospitalXiao-yan Feng - Academy of Military Medical SciencesHe-qiu Zhang - Academy of Military Medical SciencesZhi-kui Wu - Guang’anmen HospitalHui-ying Liang - Guang’anmen HospitalQuan Jiang - Guang’anmen HospitalPeng Chen - Guang’anmen HospitalHualou Liang - School of Biomedical Engineering, Science, and Health Systems (1997-)
- Publication Details
- Joint, bone, spine : revue du rhumatisme, v 82(2), pp 100-103
- Publisher
- Elsevier SAS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000352448700007
- Scopus ID
- 2-s2.0-84924505291
- Other Identifier
- 991019320712704721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Rheumatology