Journal article
Elemental Carbon Exposure at Residence and Survival After Acute Myocardial Infarction
Epidemiology (Cambridge, Mass.), v 20(4), pp 547-554
Jul 2009
PMID: 19289965
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background: Particulate air pollution has been consistently related to cardiovascular mortality. Some evidence Suggests that particulate matter may accelerate the atherosclerotic process. Effects of within-city variations of particulate air pollution on survival after an acute cardiovascular event have been little explored.
Methods: We conducted a cohort study of hospital survivors of acute myocardial infarction (MI) from file Worcester, MA, metropolitan area to investigate the long-term effects of within-city variation in traffic-related air pollution on mortality. The study builds on an ongoing community-wide investigation examining changes over time in MI incidence and case-fatality rates. We included confirmed cases of MI in 1995, 1997, 1999, 2001, and 2003. Long-term survival status was ascertained through 2005. A validated spatiotemporal land use regression model for traffic-related air pollution was developed and annual averages of elemental carbon at residence estimated. The effect of estimated elemental carbon on the long-term mortality of patients discharged after MI was analyzed using a Cox proportional hazards model, controlling for a variety of demographic, medical history, and clinical variables.
Results: Of the 3895 patients with validated MI, 44% died during follow-up. Exposure to estimated elemental carbon in the year of entry into the study was 0.44 mu g/m(3) on average. All-cause mortality increased by 15% (95% confidence interval = 0.03%-29%) per interquartile range increase in estimated yearly elemental carbon (0.24 mu g/m(3)) after the second year of survival. No association between traffic-related pollution and all-cause mortality was observed during the first 2 years of follow-up.
Conclusions: Chronic traffic-related particulate air pollution is associated with increased mortality in hospital survivors of acute MI after the second year of survival.
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Details
- Title
- Elemental Carbon Exposure at Residence and Survival After Acute Myocardial Infarction
- Creators
- Stephanie von Klot - Helmholtz Zentrum MünchenAlexandros Gryparis - Harvard UniversityCathryn Tonne - King's College LondonJeffrey Yanosky - Harvard UniversityBrent A. Coull - Harvard UniversityRobert J. Goldberg - University of Massachusetts Chan Medical SchoolDarleen Lessard - King's College LondonSteven J. Melly - Harvard UniversityHelen H. Suh - Harvard UniversityJoel Schwartz - Harvard University
- Publication Details
- Epidemiology (Cambridge, Mass.), v 20(4), pp 547-554
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 8
- Grant note
- G0801056B / Medical Research Council; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) Marie Curie International Fellowship within the 6th European Community Framework Programme; European Union (EU)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Urban Health Collaborative
- Web of Science ID
- WOS:000267065500012
- Scopus ID
- 2-s2.0-67651046266
- Other Identifier
- 991021875344404721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Public, Environmental & Occupational Health