Journal article
Elevated ALT and GGT predict all-cause mortality and hepatocellular carcinoma in Taiwanese male: a case-cohort study
Hepatology international, v 7(4), pp 1040-1049
01 Oct 2013
PMID: 26202033
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Purpose Evidence indicates a positive association between liver enzymes and the risk of death in Western countries; however, the evidence in Asian populations is scarce. We investigated the association between liver enzymes and total, cardiovascular (CVD), cancer and hepatocellular carcinoma (HCC) mortality in a cohort of Taiwanese male free of cancer at baseline.
Methods From 1996 to 2003, 54,751 Taiwanese male aged 40-80 years without cancer completed a health screening and were followed through 2005 (5.8 +/- A 2.5 years of follow-up). A random cohort of 3,961 male was selected to compare to 1,864 male who died. We used Cox proportional hazards regression models to assess the risk of all-cause, cardiovascular and cancer mortality associated with alanine aminotransferase (ALT), aspartate aminotransferase (AST) and gamma glutamyl transferase (GGT).
Results In this population, higher levels of ALT, AST and GGT were significantly associated with all-cause mortality [hazard ratio (HR) 1.2, 1.8 and 1.6 for ALT, AST and GGT, respectively; all p < 0.05], cancer mortality (HR 1.8-2.8) and HCC mortality (HR 5.5-36.1). GGT was significantly associated with CVD mortality (HR 1.2).
Conclusions In Taiwanese male free of cancer at baseline, elevations of ALT, AST and GGT were associated with future risk of all-cause death, all cancer and HCC mortality, independent of conventional risk factors, and could be used to identify male who would benefit from HCC screening.
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Details
- Title
- Elevated ALT and GGT predict all-cause mortality and hepatocellular carcinoma in Taiwanese male: a case-cohort study
- Creators
- Ruben Hernaez - Johns Hopkins MedicineHsin-Chieh Yeh - Johns Hopkins MedicineMariana Lazo - Johns Hopkins MedicineHui-Ming Chung - Mennonite Christian HospitalJames P. Hamilton - College Station Medical CenterAyman Koteish - Johns Hopkins MedicineJames J. Potter - College Station Medical CenterFrederick L. Brancati - Johns Hopkins UniversityJeanne M. Clark - Johns Hopkins Medicine
- Publication Details
- Hepatology international, v 7(4), pp 1040-1049
- Publisher
- Springer Nature
- Number of pages
- 10
- Grant note
- 7-07-MN-08 / American Diabetes Association Mentor-Based Postdoctoral Fellowship program; American Diabetes Association P60-DK-079637 / NIDDK Diabetes Research and Training Center; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) P60-DK-079637 / National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Diabetes Research and Training Center; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) P30DK079637 / NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) K24-DK-62222 / NIDDK; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Urban Health Collaborative
- Web of Science ID
- WOS:000327895800012
- Scopus ID
- 2-s2.0-84890501293
- Other Identifier
- 991020550348204721
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- Collaboration types
- International collaboration
- Web of Science research areas
- Gastroenterology & Hepatology