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Journal article
Elevated hepatic enzymes and incidence of venous thromboembolism: a prospective study
Annals of epidemiology, v 24(11), pp 817-821
01 Nov 2014
PMID: 25277506
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Abstract
Purpose: Approximately 10% of the general population has elevated blood concentrations of hepatic enzymes, which are linked to increased coagulation markers. We tested whether elevated hepatic enzymes are associated with increased risk of venous thromboembolism (VIE).
Methods: We followed 12,604 adults with measurements of alanine transaminase, aspartate aminotransferase (AST), and gamma-glutamyl transpeptidase (GGT) prospectively for VTE occurrence.
Results: AST and GGT above the laboratory normal values were associated over two decades of follow-up with increased risk of total (n = 532) and provoked VTE (n = 332), but with not unprovoked VTE (n = 200). In a model adjusted for age, race, sex, hormone replacement, alcohol intake, diabetes, body mass index, estimated glomerular filtration rate, and C-reactive protein, the hazard ratios (HR) (95% confidence interval) for high versus normal AST were 1.46 (1.00-2.11) for total VTE and 1.83 (1.21-2.79) for provoked VTE. For high GGT, the HR were 1.34 (1.06-1.69) for total VTE and 1.43 (1.07-1.91) for provoked VTE. When follow-up was limited to the first 10 years, associations were even stronger (HR approximate to 1.7 for total VFE).
Conclusions: Elevated concentrations of two hepatic enzymes (AST and GGT) in this general middle-aged population are associated with a modestly increased risk of VTE. (C) 2014 Elsevier Inc. All rights reserved.
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Details
- Title
- Elevated hepatic enzymes and incidence of venous thromboembolism: a prospective study
- Creators
- Aaron R. Folsom - University of MinnesotaPamela L. Lutsey - University of MinnesotaNicholas S. Roetker - University of MinnesotaWayne D. Rosamond - University of North Carolina at Chapel HillMariana Lazo - Johns Hopkins UniversitySusan R. Heckbert - University of WashingtonSaonli Basu - University of MinnesotaMary Cushman - University of VermontElizabeth Selvin - Johns Hopkins University
- Publication Details
- Annals of epidemiology, v 24(11), pp 817-821
- Publisher
- Elsevier
- Number of pages
- 5
- Grant note
- HHSN268201100005C; HHSN268201100006C; HHSN268201100007C; HHSN268201100008C; HHSN268201100009C; HHSN268201100010C; HHSN268201100011C; HHSN268201100012C / Atherosclerosis Risk in Communities (ARIC) Study contracts R01HL059367 / NATIONAL HEART, LUNG, AND BLOOD INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) R01DK089174 / NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) R01 DK089174 / National Institute of Diabetes and Digestive and Kidney Diseases; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) R01 HL059367 / National Heart, Lung, and Blood Institute; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Urban Health Collaborative
- Web of Science ID
- WOS:000343614700004
- Scopus ID
- 2-s2.0-84908264595
- Other Identifier
- 991020550341804721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Public, Environmental & Occupational Health