Journal article
Elevated levels of urine angiostatin and plasminogen/plasmin in cancer patients
International journal of molecular medicine, v 5(5), pp 547-598
May 2000
PMID: 10762660
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Previously, a specific angiogenesis inhibitor, angiostatin, discovered
in urine and serum of tumor-bearing mice, was reported to potently block tumor
growth and metastasis in animal models. Detection of angiostatin and its precursor
proteins in urine from cancer patients has not been reported. Now, we report the
development of an antibody-based analysis system that allows us to detect angiostatin
and plasminogen/plasmin (Pgn/plasmin) in the urine of cancer patients. The detection
system is a combination of a novel lysine-ELISA assay and Western immunoblot analysis
using a specific antibody to human angiostatin and Pgn/plasmin. High levels of
Pgn/plasmin were detected in the urine from various cancer patients, whereas healthy
individuals showed relatively low levels of urine Pgn/plasmin. Of interest, angiostatin
is detectable in urine samples of patients with various cancers, including acute
lymphoblastic leukemia, suggesting that angiogenesis may play an important role
in the development and progression of leukemia. Our data for the first time show
that angiostatin and Pgn/plasmin are present at relatively high levels in the
urine of human cancer patients. Detection of urine angiostatin in cancer patients
helps us not only to understand the role of this angiogenesis inhibitor in cancer
development and progression but also allows us to develop tools of cancer diagnosis
and prognosis. Thus angiostatin has both therapeutic and diagnostic implications
in cancer disease.
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Details
- Title
- Elevated levels of urine angiostatin and plasminogen/plasmin in cancer patients
- Creators
- Y Cao - Karolinska InstituteN Veitonmaki - Karolinska InstituteK Keough - Karolinska InstituteH Cheng - Karolinska InstitutetL S Lee - Karolinska InstituteD Zurakowski - Karolinska Institute
- Publication Details
- International journal of molecular medicine, v 5(5), pp 547-598
- Publisher
- D.A. Spandidos
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Materials Science and Engineering
- Web of Science ID
- WOS:000086506900015
- Scopus ID
- 2-s2.0-0034181854
- Other Identifier
- 991019169460004721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Medicine, Research & Experimental