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Published, Version of Record (VoR)Open Access Discount via Drexel Libraries Read and Publish Program 2025CC BY V4.0, Open
Journal article
Elevation of Plasma IL-15 and RANTES as Potential Biomarkers of Healing in Chronic Venous Ulcerations: A Pilot Study
Biomolecules, v 15(3), 395
10 Mar 2025
PMID: 40149931
Featured in Collection : Research Supported by Drexel Libraries' OA Programs
Abstract
Chronic wounds present a large burden to our healthcare system and are typically marked by a failure to transition out of the inflammatory phase of wound healing. Venous leg ulcers (VLUs) represent the largest portion of chronic wounds. A pilot study of eleven (11) patients with VLUs seen over a 12-week period was undertaken utilizing RNA sequencing of wound biopsies and plasma cytokine levels to determine if biomarkers could be identified that would distinguish between wounds which heal versus those that do not. Chronic wounds were found to have increased expression of genes relating to epithelial-to-mesenchymal transition (EMT), cartilage and bone formation, and regulation of apical junction. Plasma cytokine levels showed predictive potential for IL-15 and RANTES, which were found to increase over time in patients with healed wounds. Further research is needed to validate these biomarkers as well as additional study of other chronic wound models, such as diabetic foot ulcers (DFUs).
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Details
- Title
- Elevation of Plasma IL-15 and RANTES as Potential Biomarkers of Healing in Chronic Venous Ulcerations: A Pilot Study
- Creators
- Amanda BeneatVikki Rueda (Corresponding Author) - Drexel University, College of MedicineHardik PatelZarina Brune - Donald & Barbara Zucker School of Medicine at Hofstra/NorthwellBarbara Sherry - Donald & Barbara Zucker School of Medicine at Hofstra/NorthwellAndrew Shih - Northwell HealthSally Kaplan - Northwell HealthAmit Rao - Northwell HealthAnnette T. Lee - Northwell HealthAsha Varghese - Donald & Barbara Zucker School of Medicine at Hofstra/NorthwellAlisha Oropallo - Donald & Barbara Zucker School of Medicine at Hofstra/NorthwellBetsy J. Barnes - Donald & Barbara Zucker School of Medicine at Hofstra/Northwell
- Publication Details
- Biomolecules, v 15(3), 395
- Publisher
- MDPI
- Number of pages
- 21
- Grant note
- The Feinstein Institutes for Medical Research at Northwell HealthFeinstein Institutes for Medical Research at Northwell HealthAdvancing Women in Science and Medicine (AWSM) program
This research was funded in part by The Feinstein Institutes for Medical Research at Northwell Health and the Advancing Women in Science and Medicine (AWSM) program.
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- General Internal Medicine
- Web of Science ID
- WOS:001452832500001
- Scopus ID
- 2-s2.0-105001422706
- Other Identifier
- 991022032972504721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Biochemistry & Molecular Biology