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Journal article
Eliminating Contamination in Umbilical Cord Blood Culture Sampling for Early-Onset Neonatal Sepsis
Frontiers in pediatrics, v 9, pp 794710-794710
20 Dec 2021
PMID: 34988042
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Introduction: Despite the advantages of umbilical cord blood culture (UCBC) use for diagnosis of early onset sepsis (EOS), contamination rates have deterred neonatologists from its widespread use. We aimed to implement UCBC collection in a level III neonatal intensive care unit (NICU) and apply quality improvement (QI) methods to reduce contamination in the diagnosis of early onset sepsis.Methods: Single-center implementation study utilizing quality improvement methodology to achieve 0% contamination rate in UCBC samples using the Plan-Do-Study-Act (PDSA) model for improvement. UCBC was obtained in conjunction with peripheral blood cultures (PBC) in neonates admitted to the NICU due to maternal chorioamnionitis. Maternal and neonatal characteristics between clinical sepsis and asymptomatic groups were compared. Process, outcome, and balancing measures were monitored.Results: Eighty-two UCBC samples were collected in addition to peripheral blood culture from neonates admitted due to maternal chorioamnionitis. Ten (12%) neonates had a diagnosis of clinical sepsis. All PBCs were negative and 5 UCBCs were positive in the study period. After 2 PDSA cycles, there was special cause variation with improvement in the percent of contaminated samples from 7.3 to 0%. There was no change in antibiotic duration among asymptomatic neonates.Conclusions: Implementation of UCBC for the diagnosis of EOS in term infants is feasible and contamination can be minimized with the implementation of a core team of trained providers and a proper sterile technique without increasing antibiotic duration.
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Details
- Title
- Eliminating Contamination in Umbilical Cord Blood Culture Sampling for Early-Onset Neonatal Sepsis
- Creators
- Vilmaris Quinones Cardona - St Christophers Hosp Children, Dept Pediat, Philadelphia, PA 19134 USAVanessa Lowery - St. Christopher's Hospital for ChildrenDavid Cooperberg - St. Christopher's Hospital for ChildrenEndla K. Anday - Drexel UniversityAlison J. Carey - St. Christopher's Hospital for Children
- Publication Details
- Frontiers in pediatrics, v 9, pp 794710-794710
- Publisher
- Frontiers Media Sa
- Number of pages
- 7
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics
- Web of Science ID
- WOS:000738857500001
- Scopus ID
- 2-s2.0-85122219328
- Other Identifier
- 991019167337304721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Pediatrics