Files and links (1)
SubmittedOpen Access (License Unspecified), Open
Journal article
Elucidating amyloid beta-protein folding and assembly: A multidisciplinary approach
Accounts of chemical research, v 39(9), pp 635-645
Sep 2006
PMID: 16981680
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Oligomeric, neurotoxic amyloid protein assemblies are thought to be causative agents in Alzheimer's and other neurodegenerative diseases. Development of oligomer-specific therapeutic agents requires a mechanistic understanding of the oligomerization process. This is a daunting task because amyloidogenic protein oligomers often are metastable and comprise structurally heterogeneous populations in equilibrium with monomers and fibrils. A single methodological approach cannot elucidate the entire protein assembly process. An integrated multidisciplinary program is required. We discuss here the synergistic application of in hydro, in vacuo, and in silico methods to the study of the amyloid beta-protein, the key pathogenetic agent in Alzheimer's disease.
Metrics
Details
- Title
- Elucidating amyloid beta-protein folding and assembly: A multidisciplinary approach
- Creators
- David B Teplow - Department of Neurology, David Geffen School of Medicine, Brain Research Institute, and Molecular Biology Institute, University of California, Los Angeles, California 90095, USA. dteplow@ucla.eduNoel D LazoGal BitanSummer BernsteinThomas WyttenbachMichael T BowersAndrij BaumketnerJoan-Emma SheaBrigita UrbancLuis CruzJose BorregueroH Eugene Stanley
- Publication Details
- Accounts of chemical research, v 39(9), pp 635-645
- Publisher
- American Chemical Society; Washington, DC
- Grant note
- NS44147 / NINDS NIH HHS NS38328 / NINDS NIH HHS AG027818 / NIA NIH HHS AG18921 / NIA NIH HHS AG023661 / NIA NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Physics
- Web of Science ID
- WOS:000240572700010
- Scopus ID
- 2-s2.0-33749832945
- Other Identifier
- 991014878258504721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Chemistry, Multidisciplinary