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Emergence of system roles in normative neurodevelopment
Journal article   Open access   Peer reviewed

Emergence of system roles in normative neurodevelopment

Shi Gu, Theodore D. Satterthwaite, John D. Medaglia, Muzhi Yang, Raquel E. Gur, Ruben C. Gur and Danielle S. Bassett
Proceedings of the National Academy of Sciences - PNAS, v 112(44), pp 13681-13686
03 Nov 2015
PMID: 26483477
url
https://doi.org/10.1073/pnas.1502829112View
Published, Version of Record (VoR)Open Access (License Unspecified) Open

Abstract

Multidisciplinary Sciences Science & Technology Science & Technology - Other Topics
Adult human cognition is supported by systems of brain regions, or modules, that are functionally coherent at rest and collectively activated by distinct task requirements. However, an understanding of how the formation of these modules supports evolving cognitive capabilities has not been delineated. Here, we quantify the formation of network modules in a sample of 780 youth (aged 8-22 y) who were studied as part of the Philadelphia Neurodevelopmental Cohort. We demonstrate that the brain's functional network organization changes in youth through a process of modular evolution that is governed by the specific cognitive roles of each system, as defined by the balance of within-vs. between-module connectivity. Moreover, individual variability in these roles is correlated with cognitive performance. Collectively, these results suggest that dynamic maturation of network modules in youth may be a critical driver for the development of cognition.

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