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Journal article
Emergence of system roles in normative neurodevelopment
Proceedings of the National Academy of Sciences - PNAS, v 112(44), pp 13681-13686
03 Nov 2015
PMID: 26483477
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Adult human cognition is supported by systems of brain regions, or modules, that are functionally coherent at rest and collectively activated by distinct task requirements. However, an understanding of how the formation of these modules supports evolving cognitive capabilities has not been delineated. Here, we quantify the formation of network modules in a sample of 780 youth (aged 8-22 y) who were studied as part of the Philadelphia Neurodevelopmental Cohort. We demonstrate that the brain's functional network organization changes in youth through a process of modular evolution that is governed by the specific cognitive roles of each system, as defined by the balance of within-vs. between-module connectivity. Moreover, individual variability in these roles is correlated with cognitive performance. Collectively, these results suggest that dynamic maturation of network modules in youth may be a critical driver for the development of cognition.
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Details
- Title
- Emergence of system roles in normative neurodevelopment
- Creators
- Shi Gu - Univ Penn, Appl Math & Computat Sci, Philadelphia, PA 19104 USATheodore D. Satterthwaite - Univ Penn, Dept Psychiat, Brain Behav Lab, Philadelphia, PA 19104 USAJohn D. Medaglia - Univ Penn, Dept Bioengn, Philadelphia, PA 19104 USAMuzhi Yang - Univ Penn, Appl Math & Computat Sci, Philadelphia, PA 19104 USARaquel E. Gur - Univ Penn, Dept Psychiat, Brain Behav Lab, Philadelphia, PA 19104 USARuben C. Gur - Univ Penn, Dept Psychiat, Brain Behav Lab, Philadelphia, PA 19104 USADanielle S. Bassett - Univ Penn, Dept Bioengn, Philadelphia, PA 19104 USA
- Publication Details
- Proceedings of the National Academy of Sciences - PNAS, v 112(44), pp 13681-13686
- Publisher
- Natl Acad Sciences
- Number of pages
- 6
- Grant note
- BCS-1441502; BCS-1430087 / National Science Foundation; National Science Foundation (NSF) R01HD086888 / EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD) W911NF-10-2-0022 / Army Research Laboratory through the US Army Research Office Institute for Translational Medicine and Therapeutics at the University of Pennsylvania MH089983; MH089924 / National Institute of Mental Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH) Alfred P. Sloan Foundation Dowshen Program for Neuroscience Applied Mathematics and Computational Science Graduate Program at the University of Pennsylvania John D. and Catherine T. MacArthur Foundation R01MH107703 / NATIONAL INSTITUTE OF MENTAL HEALTH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Psychological and Brain Sciences (Psychology)
- Web of Science ID
- WOS:000364164900075
- Scopus ID
- 2-s2.0-84946593612
- Other Identifier
- 991019296575904721
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- Web of Science research areas
- Neurosciences