Journal article
Emerging Approaches for Targeting Metabolic Vulnerabilities in Malignant Glioma
Current neurology and neuroscience reports, v 16(2), pp 17-17
Feb 2016
PMID: 26759318
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Malignant gliomas are intractable and among the most lethal human malignancies. Like other cancers, metabolic reprogramming is a key feature of glioma and is thought to accommodate the heightened nutrient requirements for tumor cell proliferation, growth, and survival. This metabolic rewiring, driven by oncogenic signaling and molded by the unique environment of the brain, may impose vulnerabilities that could be exploited therapeutically for increased tumor control. In this review, we discuss the prominent metabolic features of malignant glioma, the key pathways regulating glioma metabolism, and the potential therapeutic opportunities for targeting metabolic processes.
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Details
- Title
- Emerging Approaches for Targeting Metabolic Vulnerabilities in Malignant Glioma
- Creators
- Peter M Clark - University of California, Los AngelesWilson X Mai - University of California, Los AngelesTimothy F Cloughesy - University of California, Los AngelesDavid A Nathanson - University of California, Los Angeles
- Publication Details
- Current neurology and neuroscience reports, v 16(2), pp 17-17
- Publisher
- Springer Nature
- Grant note
- P50 CA86306 / NCI NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems; Drexel University
- Web of Science ID
- WOS:000369264400007
- Scopus ID
- 2-s2.0-84973494141
- Other Identifier
- 991019356344604721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Clinical Neurology
- Neurosciences