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Emerging Priorities for Microbiome Research
Journal article   Open access   Peer reviewed

Emerging Priorities for Microbiome Research

Chad M. Cullen, Kawalpreet K. Aneja, Sinem Beyhan, Clara E. Cho, Stephen Woloszynek, Matteo Convertino, Sophie J. McCoy, Yanyan Zhang, Matthew Z. Anderson, David Alvarez-Ponce, …
Frontiers in microbiology, v 11, pp 136-136
19 Feb 2020
DOI: https://doi.org/10.3389/fmicb.2020.00136
PMID: 32140140
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://doi.org/10.3389/fmicb.2020.00136View
Published, Version of Record (VoR)CC BY V4.0,  Open

Abstract

gut microbiome microbial forensics Microbiology microbiome ecology microbiome evolution microbiome interactions prebiotics probiotics skin microbiome
Microbiome research has increased dramatically in recent years, driven by advances in technology and significant reductions in the cost of analysis. Such research has unlocked a wealth of data, which has yielded tremendous insight into the nature of the microbial communities, including their interactions and effects, both within a host and in an external environment as part of an ecological community. Understanding the role of microbiota, including their dynamic interactions with their hosts and other microbes, can enable the engineering of new diagnostic techniques and interventional strategies that can be used in a diverse spectrum of fields, spanning from ecology and agriculture to medicine and from forensics to exobiology. From June 19–23 in 2017, the NIH and NSF jointly held an Innovation Lab on Quantitative Approaches to Biomedical Data Science Challenges in our Understanding of the Microbiome . This review is inspired by some of the topics that arose as priority areas from this unique, interactive workshop. The goal of this review is to summarize the Innovation Lab’s findings by introducing the reader to emerging challenges, exciting potential, and current directions in microbiome research. The review is broken into five key topic areas: (1) interactions between microbes and the human body, (2) evolution and ecology of microbes, including the role played by the environment and microbe-microbe interactions, (3) analytical and mathematical methods currently used in microbiome research, (4) leveraging knowledge of microbial composition and interactions to develop engineering solutions, and (5) interventional approaches and engineered microbiota that may be enabled by selectively altering microbial composition. As such, this review seeks to arm the reader with a broad understanding of the priorities and challenges in microbiome research today and provide inspiration for future investigation and multi-disciplinary collaboration.

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127 citations in Web of Science
142 citations in Scopus

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UN Sustainable Development Goals (SDGs)

This publication has contributed to the advancement of the following goals:

#3 Good Health and Well-Being

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Collaboration types
Domestic collaboration
International collaboration
Web of Science research areas
Microbiology
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