Journal article
Emerging Pyrethroid Resistance among Anopheles arabiensis in Kenya
The American journal of tropical medicine and hygiene, v 98(3), pp 704-709
01 Jan 2018
PMID: 29363447
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Vector control programs, particularly in the form of insecticide-treated bed nets (ITNs), are essential for achieving malaria elimination goals. Recent reports of increasing knockdown resistance (kdr) mutation frequencies for Anopheles arabiensis in Western Kenya heightens the concern on the future effectiveness of ITNs in Kenya. We examined resistance in An. arabiensis populations across Kenya through kdr mutations and World Health Organization-recommended bioassays. We detected two kdr alleles, L1014F and L1014S. Kdr mutations were found in five of the 11 study sites, with mutation frequencies ranging from 3% to 63%. In two Western Kenya populations, the kdr L1014F allele frequency was as high as 10%. The L1014S frequency was highest at Chulaimbo at 55%. Notably, the kdr L1014F mutation was found to be associated with pyrethroid resistance at Port Victoria, but kdr mutations were not significantly associated with resistance at Chulaimbo, which had the highest kdr mutation frequency among all sites. This study demonstrated the emerging pyrethroid resistance in An. arabiensis and that pyrethroid resistance may be related to kdr mutations. Resistance monitoring and management are urgently needed for this species in Kenya where resistance is emerging and its abundance is becoming predominant. Kdr mutations may serve as a biomarker for pyrethroid resistance in An. arabiensis.
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Details
- Title
- Emerging Pyrethroid Resistance among Anopheles arabiensis in Kenya
- Creators
- Elizabeth Hemming-Schroeder - University of California, IrvineStephanie Strahl - University of California, IrvineEugene Yang - University of California, IrvineAmanda Nguyen - University of California, IrvineEugenia Lo - University of California, IrvineDaibin Zhong - University of California, IrvineHarrysone Atieli - Kenya Medical Research InstituteAndrew Githeko - Kenya Medical Research InstituteGuiyun Yan - University of California, Irvine
- Publication Details
- The American journal of tropical medicine and hygiene, v 98(3), pp 704-709
- Publisher
- Amer Soc Trop Med & Hygiene
- Number of pages
- 6
- Grant note
- U19AI129326 / NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID) R01 A1050243; D43 TW01505; U19 AI129326 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000430952800013
- Scopus ID
- 2-s2.0-85043532225
- Other Identifier
- 991022192519204721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Public, Environmental & Occupational Health
- Tropical Medicine