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Journal article
Emerging Roles for Transcription Factors During Mitosis
Cells, v 14(4), 263
12 Feb 2025
PMID: 39996736
Featured in Collection : Research Supported by Drexel Libraries' OA Programs
Abstract
The genome is dynamically reorganized, partitioned, and divided during mitosis. Despite their role in organizing interphase chromatin, transcription factors were largely believed to be mitotic spectators evicted from chromatin during mitosis, only able to reestablish their position on DNA upon entry into G1. However, a panoply of evidence now contradicts this early belief. Numerous transcription factors are now known to remain active during mitosis to achieve diverse purposes, including chromosome condensation, regulation of the centromere/kinetochore function, and control of centrosome homeostasis. Inactivation of transcription factors during mitosis results in chromosome segregation errors, key features of cancer. Moreover, active transcription and the production of centromere-derived transcripts during mitosis are also known to play key roles in maintaining chromosomal stability. Finally, many transcription factors are associated with chromosomal instability through poorly defined mechanisms. Herein, we will review the emerging roles of transcription factors and transcription during mitosis with a focus on their role in promoting the faithful segregation of sister chromatids.
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Details
- Title
- Emerging Roles for Transcription Factors During Mitosis
- Creators
- Jane Azizkhan-Clifford (Corresponding Author) - Drexel University, Biochemistry and Molecular BiologySamuel Flashner
- Publication Details
- Cells, v 14(4), 263
- Publisher
- MDPI
- Number of pages
- 22
- Grant note
- National Institutes of Health: 1L30CA264714-24S2 American Cancer Society: PF-2301151788-01-DMC
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biochemistry and Molecular Biology
- Web of Science ID
- WOS:001431879600001
- Scopus ID
- 2-s2.0-85218449174
- Other Identifier
- 991022027837704721
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- Web of Science research areas
- Cell Biology