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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Enabling individualized therapy through nanotechnology
Pharmacological research, v 62(2), pp 57-89
2010
PMCID: PMC2886806
PMID: 20045055
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Individualized medicine is the healthcare strategy that rebukes the idiomatic dogma of ‘losing sight of the forest for the trees’. We are entering a new era of healthcare where it is no longer acceptable to develop and market a drug that is effective for only 80% of the patient population. The emergence of “-omic” technologies (e.g. genomics, transcriptomics, proteomics, metabolomics) and advances in systems biology are magnifying the deficiencies of standardized therapy, which often provide little treatment latitude for accommodating patient physiologic idiosyncrasies. A personalized approach to medicine is not a novel concept. Ever since the scientific community began unraveling the mysteries of the genome, the promise of discarding generic treatment regimens in favor of patient-specific therapies became more feasible and realistic. One of the major scientific impediments of this movement towards personalized medicine has been the need for technological enablement. Nanotechnology is projected to play a critical role in patient-specific therapy; however, this transition will depend heavily upon the evolutionary development of a systems biology approach to clinical medicine based upon “-omic” technology analysis and integration. This manuscript provides a forward looking assessment of the promise of nanomedicine as it pertains to individualized medicine and establishes a technology “snapshot” of the current state of nano-based products over a vast array of clinical indications and range of patient specificity. Other issues such as market driven hurdles and regulatory compliance reform are anticipated to “self-correct” in accordance to scientific advancement and healthcare demand. These peripheral, non-scientific concerns are not addressed at length in this manuscript; however they do exist, and their impact to the paradigm shifting healthcare transformation towards individualized medicine will be critical for its success.
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- Title
- Enabling individualized therapy through nanotechnology
- Creators
- Jason H. Sakamoto - The University of Texas SystemAnne L. van de Ven - The University of Texas Health Science Center at HoustonBiana Godin - The University of Texas Health Science CenterElvin Blanco - The University of Texas Health Science CenterRita E. Serda - The University of Texas Health Science CenterAlessandro Grattoni - The University of Texas Health Science CenterArturas Ziemys - The University of Texas Health Science CenterAli Bouamrani - The University of Texas Health Science Center at HoustonTony Hu - The University of Texas Health Science Center, Department of Nanomedicine and Biomedical Engineering, 1825 Pressler Street, Suite 537A, Houston, TX 77030, USAShivakumar I. Ranganathan - The University of Texas Health Science Center at HoustonEnrica De Rosa - The University of Texas Health Science CenterJonathan O. Martinez - The University of Texas Health Science Center at HoustonChristine A. Smid - The University of Texas at AustinRachel M. Buchanan - The University of Texas at AustinSei-Young Lee - The University of Texas at AustinSrimeenakshi Srinivasan - The University of Texas Health Science Center at HoustonMatthew Landry - The University of Texas Health Science Center at HoustonAnne Meyn - The University of Texas Health Science Center at HoustonEnnio Tasciotti - The University of Texas Health Science CenterXuewu Liu - The University of Texas Health Science CenterPaolo Decuzzi - Magna Graecia UniversityMauro Ferrari - Rice University
- Publication Details
- Pharmacological research, v 62(2), pp 57-89
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Information Science (Informatics)
- Web of Science ID
- WOS:000279491400002
- Scopus ID
- 2-s2.0-77953686812
- Other Identifier
- 991019189077804721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Pharmacology & Pharmacy