Journal article
Endocannabinoid Receptor-1 and Sympathetic Nervous System Mediate the Beneficial Metabolic Effects of Gastric Bypass
Cell reports (Cambridge), v 33(4), 108270
27 Oct 2020
PMID: 33113371
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The exact mechanisms underlying the metabolic effects of bariatric surgery remain unclear. Here, we demonstrate, using a combination of direct and indirect calorimetry, an increase in total resting metabolic rate (RMR) and specifically anaerobic RMR after Roux-en-Y gastric bypass (RYGB), but not sleeve gastrectomy (SG). We also show an RYGB-specific increase in splanchnic sympathetic nerve activity and “browning” of visceral mesenteric fat. Consequently, selective splanchnic denervation abolishes all beneficial metabolic outcomes of gastric bypass that involve changes in the endocannabinoid signaling within the small intestine. Furthermore, we demonstrate that administration of rimonabant, an endocannabinoid receptor-1 (CB1) inverse agonist, to obese mice mimics RYGB-specific effects on energy balance and splanchnic nerve activity. On the other hand, arachidonoylethanolamide (AEA), a CB1 agonist, attenuates the weight loss and metabolic signature of this procedure. These findings identify CB1 as a key player in energy regulation post-RYGB via a pathway involving the sympathetic nervous system.
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•RYGB, but not SG, increases energy expenditure (EE) and RMR•This increase in EE is due to sympathetic-mediated “browning” of mesenteric fat•CB1 inverse agonist induces splanchnic nerve activity and fat thermogenesis•CB1 agonist attenuates the RYGB-induced weight loss and “browning” of mesenteric fat
Ye et al. show that energy regulation differs between Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) where only RYGB enhances splanchnic nerve activity, to induce visceral fat thermogenesis, and increases resting metabolic rate (RMR). This sympathetic-mediated “browning” of visceral fat seems to be dependent on endocannabinoid receptor-1 (CB1) signaling.
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Details
- Title
- Endocannabinoid Receptor-1 and Sympathetic Nervous System Mediate the Beneficial Metabolic Effects of Gastric Bypass
- Creators
- Yuanchao Ye - University of IowaMarwa Abu El Haija - Stanford UniversityDonald A. Morgan - University of IowaDeng Guo - University of IowaYang Song - China Medical UniversityAaron Frank - Cedars-Sinai Medical CenterLiping Tian - China Pharmaceutical UniversityRuth A. Riedl - University of IowaColin M.L. Burnett - University of IowaZhan Gao - University of IowaZhiyong Zhu - University of IowaShailesh K. Shahi - University of IowaKasra Zarei - University of IowaAnne Couvelard - Centre de Recherche sur l'InflammationNicolas Poté - Centre de Recherche sur l'InflammationLara Ribeiro-Parenti - Centre de Recherche sur l'InflammationAndré Bado - Centre de Recherche sur l'InflammationLama Noureddine - University of IowaAndrew Bellizzi - University of IowaPaul Kievit - Oregon National Primate Research CenterAshutosh K. Mangalam - University of IowaLeonid V. Zingman - University of IowaMaude Le Gall - Centre de Recherche sur l'InflammationJustin L. Grobe - Medical College of WisconsinLee M. Kaplan - Massachusetts General HospitalDeborah Clegg - Drexel UniversityKamal Rahmouni - University of IowaMohamad Mokadem - University of Iowa
- Publication Details
- Cell reports (Cambridge), v 33(4), 108270
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Web of Science ID
- WOS:000582721000001
- Scopus ID
- 2-s2.0-85094561791
- Other Identifier
- 991019357626704721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Cell Biology