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Journal article
Endocannabinoids, stress signaling, and the locus coeruleus-norepinephrine system
Neurobiology of stress, v 11, pp 100176-100176
01 Nov 2019
PMID: 31236436
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The endocannabinoid (eCB) system has been implicated in a variety of physiological functions due to abundant expression of its receptors and endogenous ligands in the central nervous system. Substantial progress has been made in understanding how the eCB system influences the brain norepinephrine (NE) system, an important neurochemical target in the continued development of new therapies for stress-induced psychiatric disorders. We, and others, have characterized the neuroanatomical, biochemical and pharmacological effects of cannabinoid receptor modulation on brain noradrenergic circuitry and defined how molecular elements of the eCB system are positioned to directly impact the locus coeruleus (LC)-prefrontal cortex pathway, a neural circuit well recognized for contributing to symptoms of hyperarousal, a key pathophysiological feature of stress-related disorders. We also described molecular and electrophysiological properties of LC noradrenergic neurons and NE release in the medial prefrontal cortex under conditions of cannabinoid type 1 receptor deletion. Finally, we identified how stress influences cannabinoid modulation of the coeruleo-cortical pathway. A number of significant findings emerged from these studies that will be summarized in the present review and have important implications for clinical studies targeting the eCB system in the treatment of stress-induced psychiatric disorders.
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Details
- Title
- Endocannabinoids, stress signaling, and the locus coeruleus-norepinephrine system
- Creators
- Ryan R. Wyrofsky - Drexel UniversityBeverly A. S. Reyes - Drexel UniversityXiao-Yan Zhang - Children's Hospital of PhiladelphiaSeema Bhatnagar - Children's Hospital of PhiladelphiaLynn G. Kirby - Temple UniversityElisabeth J. Van Bockstaele - Drexel University
- Publication Details
- Neurobiology of stress, v 11, pp 100176-100176
- Publisher
- Elsevier
- Number of pages
- 13
- Grant note
- R01MH093981 / NATIONAL INSTITUTE OF MENTAL HEALTH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH) P30DA013429 / NATIONAL INSTITUTE ON DRUG ABUSE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Drug Abuse (NIDA); European Commission DA020129; P30 DA013429; MH093981 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:000500476200012
- Scopus ID
- 2-s2.0-85067282261
- Other Identifier
- 991019185108404721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Neurosciences